Spermatogenesis is a complex process that originates in a small population of spermatogonial
stem cells. Here we report the in vitro culture of spermatogonial stem cells that proliferate …

Although germline cells can form multipotential embryonic stem (ES)/embryonic germ (EG)
cells, these cells can be derived only from embryonic tissues, and such multipotent cells have …

Stromal cell-derived factors 1α and 1β are small cytokines belonging to the intercrine CXC
subfamily and originally isolated from a murine bone-marrow stroma cell line by the signal …

Although spermatogenesis is essential for reproduction, little is known about spermatogonial
stem cells. These cells provide the basis for spermatogenesis throughout adult life by …

The spermatogonial stem cell initiates and maintains spermatogenesis in the testis. To
perform this role, the stem cell must self replicate as well as produce daughter cells that can …

Spermatogonial stem cells are the only stem cells in the body that transmit genetic information
to the next generation. These cells can be cultured for extended periods in the presence …

A cDNA encoding mouse PD-1, a member of the immunoglobulin superfamily was previously
isolated from apoptosis-induced cells by subattractive hybridization. To determine the …

Spermatogenesis is dependent on a small population of stem cells. Despite the biological
significance of spermatogonial stem cells, their analysis has been hampered by their scarcity. …

Little is known about stem cell biology or the specialized environments or niches believed to
control stem cell renewal and differentiation in self-renewing tissues of the body. Functional …

Spermatogenesis originates from spermatogonial stem cells (SSCs). Development of the
spermatogonial transplantation technique in 1994 provided the first functional assay to …