Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
CD4 + T regulatory cells (T regs ), which express the Foxp3 transcription factor, play a critical
role in the maintenance of immune homeostasis. Here, we show that in mice, T regs were …
role in the maintenance of immune homeostasis. Here, we show that in mice, T regs were …
Mincle is an ITAM-coupled activating receptor that senses damaged cells
Macrophage-inducible C-type lectin (Mincle) is expressed mainly in macrophages and is
induced after exposure to various stimuli and stresses. Here we show that Mincle selectively …
induced after exposure to various stimuli and stresses. Here we show that Mincle selectively …
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
Programmed cell death 1 (PD-1) is a negative costimulatory receptor critical for the
suppression of T cell activation in vitro and in vivo. Single cell imaging elucidated a molecular …
suppression of T cell activation in vitro and in vivo. Single cell imaging elucidated a molecular …
Single App knock-in mouse models of Alzheimer's disease
T Saito, Y Matsuba, N Mihira, J Takano, P Nilsson… - Nature …, 2014 - nature.com
Experimental studies of Alzheimer's disease have largely depended on transgenic mice
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
Potent amyloidogenicity and pathogenicity of Aβ43
T Saito, T Suemoto, N Brouwers, K Sleegers… - Nature …, 2011 - nature.com
The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent
in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the …
in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the …
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
T cell receptor (TCR) activation and signaling precede immunological synapse formation and
are sustained for hours after initiation. However, the precise physical sites of the initial and …
are sustained for hours after initiation. However, the precise physical sites of the initial and …
Effects of resin hydrophilicity on water sorption and changes in modulus of elasticity
As acidic monomers of self-etching adhesives are incorporated into dental adhesives at
high concentrations, the adhesive becomes more hydrophilic. Water sorption by polymers …
high concentrations, the adhesive becomes more hydrophilic. Water sorption by polymers …
Multifunctional alloys obtained via a dislocation-free plastic deformation mechanism
T Saito, T Furuta, JH Hwang, S Kuramoto, K Nishino… - Science, 2003 - science.org
We describe a group of alloys that exhibit “super” properties, such as ultralow elastic modulus,
ultrahigh strength, super elasticity, and super plasticity, at room temperature and that …
ultrahigh strength, super elasticity, and super plasticity, at room temperature and that …
Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation
T Saito, N Iwata, S Tsubuki, Y Takaki, J Takano… - Nature medicine, 2005 - nature.com
Expression of somatostatin in the brain declines during aging in various mammals including
apes and humans 1 , 2 . A prominent decrease in this neuropeptide also represents a …
apes and humans 1 , 2 . A prominent decrease in this neuropeptide also represents a …
Interaction of tyrosine-based sorting signals with clathrin-associated proteins
…, MC Fournier, H Bosshart, I Rhee, S Miyatake, T Saito… - Science, 1995 - science.org
Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins mediate
clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast two-…
clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast two-…