Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a
frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its …

Background Aside from idiopathic Parkinson syndrome (Parkinson’s disease), there are a
number of other, so-called atypical parkinsonian syndromes: dementia with Lewy bodies (DLB)…

Background: Dementia results from heterogeneous diseases of the brain. Mixed disease
forms are increasingly recognized. Methods: We performed a survey within brain banks of …

Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria,
published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for …

Assessment of Alzheimer’s disease (AD)-related neurofibrillary pathology requires a procedure
that permits a sufficient differentiation between initial, intermediate, and late stages. The …

Expansion of a GGGGCC hexanucleotide repeat upstream of the C9orf72 coding region is the
most common cause of familial frontotemporal lobar degeneration and amyotrophic lateral …

… were rare in neuromelanin containing neurons of the substantia nigra (r, arrow), in remaining
motoneurons (s, arrow and detail) and in posterior horn cells of the lumbar spinal cord (t). …

It has been recognized that molecular classifications will form the basis for neuropathological
diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's …

Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology
in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes…

Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated
with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding …