User profiles for T. A. Mace
 | Thomas A MaceThe Ohio State University Verified email at osumc.edu Cited by 3698 |
IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer
Objective Limited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma
(PDAC) has prompted investigation into combination therapy. We hypothesised that …
(PDAC) has prompted investigation into combination therapy. We hypothesised that …
Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner
TA Mace, Z Ameen, A Collins, S Wojcik, M Mair… - Cancer research, 2013 - AACR
Pancreatic stellate cells (PSC) are a subset of pancreatic cancer-associated fibroblasts.
These cells provide prosurvival signals to tumors; however, little is known regarding their …
These cells provide prosurvival signals to tumors; however, little is known regarding their …
Nitric oxide production by myeloid-derived suppressor cells plays a role in impairing Fc receptor–mediated natural killer cell function
…, P Trikha, B Mundy-Bosse, E McMichael, TA Mace… - Clinical Cancer …, 2018 - AACR
Purpose: mAbs are used to treat solid and hematologic malignancies and work in part through
Fc receptors (FcRs) on natural killer cells (NK). However, FcR-mediated functions of NK …
Fc receptors (FcRs) on natural killer cells (NK). However, FcR-mediated functions of NK …
[HTML][HTML] Randomized phase 2 trial of the oncolytic virus pelareorep (Reolysin) in upfront treatment of metastatic pancreatic adenocarcinoma
…, S Pant, S Aparo, J Sexton, JL Marshall, TA Mace… - Molecular Therapy, 2016 - cell.com
Pelareorep causes oncolysis in tumor cells with activated Ras. We hypothesized that
pelareorep would have efficacy and immunomodulatory activity in metastatic pancreatic …
pelareorep would have efficacy and immunomodulatory activity in metastatic pancreatic …
Lipocalin-2 promotes pancreatic ductal adenocarcinoma by regulating inflammation in the tumor microenvironment
Lipocalin-2 (LCN2) promotes malignant development in many cancer types. LCN2 is
upregulated in patients with pancreatic ductal adenocarcinoma (PDAC) and in obese individuals, …
upregulated in patients with pancreatic ductal adenocarcinoma (PDAC) and in obese individuals, …
[HTML][HTML] Generation of monocyte-derived tumor-associated macrophages using tumor-conditioned media provides a novel method to study tumor-associated …
…, JH Howard, RA Baiocchi, TA Mace… - … for immunotherapy of …, 2019 - Springer
Background Tumor-associated macrophages (TAM) are expanded and exhibit tumor-promoting
properties within the tumor microenvironment. Current methods to study TAM have not …
properties within the tumor microenvironment. Current methods to study TAM have not …
Differentiation of CD8+ T cells into effector cells is enhanced by physiological range hyperthermia
TA Mace, L Zhong, C Kilpatrick, E Zynda… - Journal of leukocyte …, 2011 - academic.oup.com
In this study, we asked whether exposure to different physiologically relevant temperatures (33C,
37C, and 39.5C) could affect subsequent antigen-specific, activation-related events of …
37C, and 39.5C) could affect subsequent antigen-specific, activation-related events of …
Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells
Background Pancreatic cancer cells exist in a hypoxic microenvironment containing numerous
factors that impact tumor survival, proliferation, and metastasis. MicroRNAs (miRs) are …
factors that impact tumor survival, proliferation, and metastasis. MicroRNAs (miRs) are …
Effector CD8+ T cell IFN-γ production and cytotoxicity are enhanced by mild hyperthermia
TA Mace, L Zhong, KM Kokolus… - International Journal of …, 2012 - Taylor & Francis
Purpose: Clinical trials combining hyperthermia with radiation and/or chemotherapy for cancer
treatment have resulted in improved overall survival and control of local recurrences. The …
treatment have resulted in improved overall survival and control of local recurrences. The …
Systemic immune activity predicts overall survival in treatment-naive patients with metastatic pancreatic cancer
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year
survival rate <7% and is ultimately refractory to most treatments. To date, an assessment of …
survival rate <7% and is ultimately refractory to most treatments. To date, an assessment of …