INTRODUCTION A disease is rarely a straightforward consequence of an abnormality in a
single gene, but rather reflects the interplay of multiple molecular processes. The …

The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …

The observation that disease associated proteins often interact with each other has fueled
the development of network-based approaches to elucidate the molecular mechanisms of …

Recent advances in genetics have spurred rapid progress towards the systematic identification
of genes involved in complex diseases. Still, the detailed understanding of the molecular …

Genes carrying mutations associated with genetic diseases are present in all human cells;
yet, clinical manifestations of genetic diseases are usually highly tissue-specific. Although …

Historically, human diseases have been differentiated and categorized based on the organ
system in which they primarily manifest. Recently, an alternative view is emerging that …

Tumor necrosis factor- α \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym}
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With the availability of large-scale data, it is now possible to systematically study the underlying
interaction maps of many complex systems in multiple disciplines. Statistical physics has …

This study describes two complementary methods that use network-based and sequence
similarity tools to identify drug repurposing opportunities predicted to modulate viral proteins. …

This document is organized as follows: In Section II we describe in detail all biological data
we use and how we analyze them. In Section III we discuss network-based measures of …