[PDF][PDF] Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells

…, R Gurlich, R Stocker, Y Zhou, MV Berridge, S Park… - Cell metabolism, 2019 - cell.com
Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they reconstitute
oxidative phosphorylation (OXPHOS) by mitochondria acquired from host stroma. To …

Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion

SW Kim, Y Jin, JH Shin, ID Kim, HK Lee, S Park… - Neurobiology of …, 2012 - Elsevier
High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In a
previous report, we showed that HMGB1 is massively released during NMDA-induced acute …

[HTML][HTML] Diagnosis of bladder cancer and prediction of survival by urinary metabolomics

X Jin, SJ Yun, P Jeong, IY Kim, WJ Kim, S Park - Oncotarget, 2014 - ncbi.nlm.nih.gov
Bladder cancer (BC) is a common cancer but diagnostic modalities, such as cystoscopy and
urinary cytology, have limitations. Here, high-performance liquid chromatography-…

[HTML][HTML] Urine-NMR metabolomics for screening of advanced colorectal adenoma and early stage colorectal cancer

ER Kim, HN Kwon, H Nam, JJ Kim, S Park, YH Kim - Scientific reports, 2019 - nature.com
Although colorectal cancer (CRC) is considered one of the most preventable cancers, no
non-invasive, accurate diagnostic tool to screen CRC exists. We explored the potential of urine …

A new NMR-based metabolomics approach for the diagnosis of biliary tract cancer

H Wen, SS Yoo, J Kang, HG Kim, JS Park, S Jeong… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Biliary tract cancer is highly lethal at presentation, with increasing
mortality worldwide. Current diagnostic measures employing multiple criteria such as imaging…

NMR-based metabolomics approach for the differentiation of ginseng (Panax ginseng) roots from different origins

…, S Kang, HN Kwon, JH Park, SW Kwon, S Park - Archives of pharmacal …, 2008 - Springer
Agro-herbal materials vary in prices and qualities depending on the origin and age and the
differentiation is both scientific and public health issue. Here, we describe a metabolomics …

Application of a 1H Nuclear Magnetic Resonance (NMR) Metabolomics Approach Combined with Orthogonal Projections to Latent Structure-Discriminant Analysis as …

…, HN Kwon, H Wen, CH Lee, M Park… - Journal of agricultural …, 2008 - ACS Publications
Correct identification of the origins of herbal medical products is becoming increasingly
important in tandem with the growing interest in alternative medicine. However, visual inspection …

[HTML][HTML] Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

…, N Kim, YS Yuk, SY Cha, Y Lee, JK Ryu, S Park… - Nature …, 2017 - nature.com
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate
pathway (PPP) during epithelial–mesenchymal transition (EMT) is not well-understood. Here …

[PDF][PDF] Psat1-dependent fluctuations in α-ketoglutarate affect the timing of ESC differentiation

…, JH Kim, YA Kim, YK Jeon, DH Chung, X Jin, S Park… - Cell metabolism, 2016 - cell.com
Embryonic stem cells (ESCs) undergo coordinated epigenetic and metabolic changes to
differentiate properly. However, the precise mechanisms by which these alterations are fine-…

A serum marker for early pancreatic cancer with a possible link to diabetes

…, SS Hong, KH Jung, S Kang, MS Park… - JNCI: Journal of the …, 2022 - academic.oup.com
Background Pancreatic cancer (PC) has a grim prognosis, and an early diagnostic biomarker
has been highly desired. The molecular link between diabetes and PC has not been well …