User profiles for Sukhleen Kour
 | Sukhleen Kourpostdoctoral research associate Verified email at pitt.edu Cited by 636 |
[HTML][HTML] FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
…, T Distler, P Heisterkamp, EN Anderson, S Kour… - Acta …, 2019 - Springer
Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by motor neuron
degeneration and associated with aggregation of nuclear RNA-binding proteins (RBPs), including …
degeneration and associated with aggregation of nuclear RNA-binding proteins (RBPs), including …
Long noncoding RNAs in aging and age-related diseases
Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-dependent
intricate biological process characterised by the cumulative decline in the …
intricate biological process characterised by the cumulative decline in the …
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
…, I Poser, A Pal, T Doeleman, S Kishigami, S Kour… - 2019 - europepmc.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with few avenues for
treatment. Many proteins implicated in ALS associate with stress granules, which are examples …
treatment. Many proteins implicated in ALS associate with stress granules, which are examples …
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases,
including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (…
including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (…
[PDF][PDF] Nucleocytoplasmic proteomic analysis uncovers eRF1 and nonsense-mediated decay as modifiers of ALS/FTD C9orf72 toxicity
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a hexanucleotide repeat expansion in C9orf72 (C9-HRE). While RNA and …
dementia (FTD) is a hexanucleotide repeat expansion in C9orf72 (C9-HRE). While RNA and …
[HTML][HTML] Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder
S Kour, DS Rajan, TR Fortuna, EN Anderson… - Nature …, 2021 - nature.com
GEMIN5, an RNA-binding protein is essential for assembly of the survival motor neuron (SMN)
protein complex and facilitates the formation of small nuclear ribonucleoproteins (snRNPs…
protein complex and facilitates the formation of small nuclear ribonucleoproteins (snRNPs…
[HTML][HTML] RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM
Background Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative
disease characterized by progressive loss of upper and lower motor neurons. While …
disease characterized by progressive loss of upper and lower motor neurons. While …
SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration
TR Fortuna, S Kour, AV Chimata, A Muiños-Bühl… - Acta …, 2023 - Springer
GEMIN5 is essential for core assembly of small nuclear Ribonucleoproteins (snRNPs), the
building blocks of spliceosome formation. Loss-of-function mutations in GEMIN5 lead to a …
building blocks of spliceosome formation. Loss-of-function mutations in GEMIN5 lead to a …
NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein
…, C Guzman-Cardozo, S Kour… - Proceedings of the …, 2023 - National Acad Sciences
Nogo-66 receptor 1 (NgR1) binds a variety of structurally dissimilar ligands in the adult
central nervous system to inhibit axon extension. Disruption of ligand binding to NgR1 and …
central nervous system to inhibit axon extension. Disruption of ligand binding to NgR1 and …
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner
Mutations in the RNA binding protein, Fused in Sarcoma (FUS), lead to amyotrophic lateral
sclerosis (ALS), the most frequent form of motor neuron disease. Cytoplasmic aggregation …
sclerosis (ALS), the most frequent form of motor neuron disease. Cytoplasmic aggregation …