[PDF][PDF] Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress
…, JG Davis, K Ramachandran, S Uthayabalan… - Cell reports, 2023 - cell.com
The most abundant cellular divalent cations, Mg 2+ (mM) and Ca 2+ (nM-μM), antagonistically
regulate divergent metabolic pathways with several orders of magnitude affinity preference…
regulate divergent metabolic pathways with several orders of magnitude affinity preference…
The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity
Mitochondrial RNA splicing 2 (MRS2) forms a magnesium (Mg 2+ ) entry protein channel in
mitochondria. Whereas MRS2 contains two transmembrane domains constituting a pore on …
mitochondria. Whereas MRS2 contains two transmembrane domains constituting a pore on …
MRS2: A Prospective Drug Target in Gastric Cancer
S Uthayabalan - 2023 - ir.lib.uwo.ca
Mitochondrial-RNA-splicing-protein-2 (MRS2) is a magnesium (Mg2+) protein channel
localized within mitochondria. In gastric cancer (GC), the over-expression of MRS2 in malignant …
localized within mitochondria. In gastric cancer (GC), the over-expression of MRS2 in malignant …
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4
T Bishop, PJ Ratcliffe - Science Signaling, 2020 - science.org
The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body
has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. …
has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. …
Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution
S Eshaghi, D Niegowski, A Kohl, DM Molina, SA Lesley… - Science, 2006 - science.org
CorA family members are ubiquitously distributed transporters of divalent metal cations and
are considered to be the primary Mg 2+ transporter of Bacteria and Archaea. We have …
are considered to be the primary Mg 2+ transporter of Bacteria and Archaea. We have …
Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D
B Chaigne-Delalande, FY Li, GM O'Connor, MJ Lukacs… - Science, 2013 - science.org
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free
magnesium (Mg 2+ ) concentrations. Individuals with genetic deficiencies in MAGT1 have high …
magnesium (Mg 2+ ) concentrations. Individuals with genetic deficiencies in MAGT1 have high …
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
M Grunewald, S Kumar, H Sharife, E Volinsky… - Science, 2021 - science.org
INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial-…
other blood-borne substances and, in certain settings, also for the provision of endothelial-…