During angiogenesis, endothelial cells undergo proliferation, reorganization, and stabilization
to establish a mature vascular network. This process is critical for establishing a functional …

Thymocytes carrying MHC class I–restricted TCRs differentiate into CD8 T cells, while those
recognizing MHC class II become CD4 T cells. The mechanisms underlying how MHC class …

PURPOSE: The purpose of this study was to develop a critical thinking disposition scale for
nursing students. METHOD: The developmental process was construction of a conceptual …

Genome-wide association studies (GWAS) in several populations have demonstrated significant
association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)…

TYK2 is a JAK family protein tyrosine kinase activated in response to multiple cytokines,
including type I IFNs, IL-6, IL-10, IL-12, and IL-23. Extensive studies of mice that lack TYK2 …

The ERK5 mitogen-activated protein kinase (MAPK) differs from other MAPKs in possessing
a potent transcriptional activation domain. ERK5 −/− embryos die from angiogenic defects, …

Autoimmune diseases affect roughly 5-10% of the total population, with women affected more
than men. The standard treatment for autoimmune or autoinflammatory diseases had long …

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as
psoriasis and inflammatory bowel diseases (IBD), by selective targeting of TYK2. Hit triage, …

Herein we report our lead optimization effort to identify potent, selective, and orally
bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design to …

FADD is an adaptor known to transmit apoptotic signals from members of the tumor necrosis
factor receptor family. We show here that FADD has a domain implicated in cell proliferation…