MicroRNAs (miRNAs) are a class of small RNAs that act post-transcriptionally to regulate
messenger RNA stability and translation. To elucidate how miRNAs mediate their repressive …

MicroRNAs and heterogeneous ribonucleoproteins (hnRNPs) are posttranscriptional gene
regulators that bind mRNA in a sequence-specific manner. Here, we report that loss of miR-…

The antigen-induced DNA synthetic response of a number of different thymocyte populations
was studied in the spleens of lethally irradiated recipients by incorporation of 125 I 5-iodo-2-…

The poly(C) binding proteins (PCBPs) are encoded at five dispersed loci in the mouse and
human genomes. These proteins, which can be divided into two groups, hnRNPs K/J and the …

A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted
mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D …

Accumulation of globin mRNAs during erythroid differentiation is dependent on their
extraordinary stability. The longevity of human alpha‐globin mRNA is associated with a …

mRNA surveillance pathways selectively clear defective mRNAs from the cell. As such, these
pathways serve as important modifiers of genetic disorders. Nonsense-mediated decay (…

Notch is needed for T-cell development and is a common oncogenic driver in T-cell acute
lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical target of Notch in normal …

Assembly of a sequence-specific RNA–protein complex on the 3′ untranslated region (3′UTR)
of human α-globin mRNA (α-complex) correlates with mRNA stabilization. Here we …

Protein-protein interactions resulting in dimerization and heterodimerization are of central
importance in the control of gene expression and cell function. Proteins that share the 52-…