Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However,
DNA copy number and gene expression signatures indicate differences between adult and …

… Steffen Albrecht Steffen Albrecht is a research assistant and PhD candidate in the department
of Technology Assessment at Hamburg University of Technology. His current research …

Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental
states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal …

Brainstem gliomas (BSG) are a rare group of central nervous system tumors that arise mostly
in children and usually portend a particularly poor prognosis. We report the development of …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable
heterogeneity. We have recently identified recurrent H3F3A mutations affecting two …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are
devastating brain tumors with no effective therapy. Here, we investigated clinical and biological …

Purpose Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic
mismatch repair deficiency (bMMRD) is a highly penetrant childhood cancer syndrome …

Hepatoblastomas (HBs) are embryonal tumors affecting young children and representing
the most frequent malignant liver tumors in childhood. The molecular pathogenesis of HB is …