User profiles for Stefan H Oehlers
Stefan OehlersPrincipal Investigator, A*STAR Infectious Diseases Labs Verified email at idlabs.a-star.edu.sg Cited by 2504 |
Interception of host angiogenic signalling limits mycobacterial growth
Pathogenic mycobacteria induce the formation of complex cellular aggregates called
granulomas that are the hallmark of tuberculosis 1 , 2 . Here we examine the development and …
granulomas that are the hallmark of tuberculosis 1 , 2 . Here we examine the development and …
[PDF][PDF] Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production
Evidence suggests the bactericidal activity of mitochondria-derived reactive oxygen species
(mROS) directly contributes to killing phagocytozed bacteria. Infection-responsive …
(mROS) directly contributes to killing phagocytozed bacteria. Infection-responsive …
[PDF][PDF] Macrophage epithelial reprogramming underlies mycobacterial granuloma formation and promotes infection
…, AF Rosenberg, JW Saelens, MG Johnson, SH Oehlers… - Immunity, 2016 - cell.com
Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which
are tightly organized immune cell aggregates that are the central structure of tuberculosis. …
are tightly organized immune cell aggregates that are the central structure of tuberculosis. …
A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents
SH Oehlers, MV Flores, KS Okuda… - Developmental …, 2011 - Wiley Online Library
Inflammatory bowel disease (IBD) results from dysfunctional interactions between the intestinal
immune system and microbiota, influenced by host genetic susceptibility. Because a key …
immune system and microbiota, influenced by host genetic susceptibility. Because a key …
[PDF][PDF] A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization
The central pathogen-immune interface in tuberculosis is the granuloma, a complex host
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …
[PDF][PDF] Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide
CJ Hall, MV Flores, SH Oehlers, LE Sanderson… - Cell stem cell, 2012 - cell.com
Hematopoietic stem cells (HSCs) are rare multipotent cells that contribute to all blood lineages.
During inflammatory stress, hematopoietic stem and progenitor cells (HSPCs) can be …
During inflammatory stress, hematopoietic stem and progenitor cells (HSPCs) can be …
The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish
SH Oehlers, MV Flores, CJ Hall… - Disease models & …, 2011 - journals.biologists.com
Inflammatory bowel disease (IBD), in the form of Crohn’s disease (CD) or ulcerative colitis (UC),
is a debilitating chronic immune disorder of the intestine. A complex etiology resulting …
is a debilitating chronic immune disorder of the intestine. A complex etiology resulting …
Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis
SH Oehlers, MV Flores, CJ Hall… - Disease models & …, 2012 - journals.biologists.com
Exposure to retinoids for the treatment of acne has been linked to the etiology of inflammatory
bowel disease (IBD). The intestinal mucus layer is an important structural barrier that is …
bowel disease (IBD). The intestinal mucus layer is an important structural barrier that is …
[HTML][HTML] Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish
Prevalence of Mycobacterium abscessus infections is increasing in patients with respiratory
comorbidities. After initial colonisation, M. abscessus smooth colony (S) variants can …
comorbidities. After initial colonisation, M. abscessus smooth colony (S) variants can …
Live imaging of host-parasite interactions in a zebrafish infection model reveals cryptococcal determinants of virulence and central nervous system invasion
JL Tenor, SH Oehlers, JL Yang, DM Tobin, JR Perfect - MBio, 2015 - Am Soc Microbiol
The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range
of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models …
of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models …