User profiles for Sophie G Kellaway
 | Sophie KellawayAssistant Professor, University of Nottingham Verified email at nottingham.ac.uk Cited by 121 |
[PDF][PDF] Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth
Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations.
Previously, we showed that each mutational subtype develops its specific gene regulatory …
Previously, we showed that each mutational subtype develops its specific gene regulatory …
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal
…, YT Dai, Z Chen, SJ Chen, SG Kellaway… - Blood, The Journal …, 2022 - ashpublications.org
In an effort to identify novel drugs targeting fusion-oncogene–induced acute myeloid leukemia
(AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE)-driven AML, …
(AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE)-driven AML, …
Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia
The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia.
Relapse can be associated with a lineage switch from acute lymphoblastic to acute …
Relapse can be associated with a lineage switch from acute lymphoblastic to acute …
[HTML][HTML] Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth
and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to …
and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to …
[HTML][HTML] Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy caused by
mutations in genes encoding transcriptional and epigenetic regulators together with signaling …
mutations in genes encoding transcriptional and epigenetic regulators together with signaling …
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
Mutations of the haematopoietic master regulator RUNX1 are associated with acute myeloid
leukaemia, familial platelet disorder and other haematological malignancies whose …
leukaemia, familial platelet disorder and other haematological malignancies whose …
[HTML][HTML] Molecular basis of hematological disease caused by inherited or acquired RUNX1 mutations
Highlights • Germline and acquired RUNX1 mutations are associated with FPD and MDS/AML.
• Large deletions and nonsense mutations are more common in germline FPD patients. • …
• Large deletions and nonsense mutations are more common in germline FPD patients. • …
[HTML][HTML] RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks
SG Kellaway, P Keane, E Kennett, C Bonifer - haematologica, 2021 - ncbi.nlm.nih.gov
Hematological malignancies are characterized by a block in differentiation, which in many
cases is caused by recurrent mutations affecting the activity of hematopoietic transcription …
cases is caused by recurrent mutations affecting the activity of hematopoietic transcription …
[HTML][HTML] Gene regulation in t (6; 9) DEK:: NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS …
S Potluri, SG Kellaway, DJL Coleman, P Keane… - Leukemia, 2024 - nature.com
Acute Myeloid Leukemia (AML) represents a heterogeneous group of hematological
malignancies. The t (6; 9)(p23; q34) translocation, generating the DEK:: NUP214 fusion protein is …
malignancies. The t (6; 9)(p23; q34) translocation, generating the DEK:: NUP214 fusion protein is …
Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth
Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth
and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to …
and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to …