User profiles for Songhai Tian
Songhai TianPeking University School of Pharmaceutical Sciences Verified email at pku.edu.cn Cited by 930 |
Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis
Bacterial nucleoid-associated proteins play important roles in chromosome organization
and global gene regulation. We find that Lsr2 of Mycobacterium tuberculosis is a unique …
and global gene regulation. We find that Lsr2 of Mycobacterium tuberculosis is a unique …
[HTML][HTML] Shiga toxins: An update on host factors and biomedical applications
Shiga toxins (Stxs) are classic bacterial toxins and major virulence factors of toxigenic Shigella
dysenteriae and enterohemorrhagic Escherichia coli (EHEC). These toxins recognize a …
dysenteriae and enterohemorrhagic Escherichia coli (EHEC). These toxins recognize a …
[HTML][HTML] Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two C. difficile
exotoxins (TcdA and TcdB) are major virulence factors associated with these infections, and …
exotoxins (TcdA and TcdB) are major virulence factors associated with these infections, and …
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Clostridium difficile toxin A (TcdA) is a major exotoxin contributing to disruption of the colonic
epithelium during C. difficile infection. TcdA contains a carbohydrate-binding combined …
epithelium during C. difficile infection. TcdA contains a carbohydrate-binding combined …
[PDF][PDF] Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors
Enterococci are a part of human microbiota and a leading cause of multidrug resistant
infections. Here, we identify a family of Enterococcus pore-forming toxins (Epxs) in E. faecalis, E. …
infections. Here, we identify a family of Enterococcus pore-forming toxins (Epxs) in E. faecalis, E. …
Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18
Inhibitors of Bcl-X L /Bcl-2 can induce autophagy by releasing the autophagic protein Beclin
1 from its complexes with these proteins. Here we report a novel compound targeting the …
1 from its complexes with these proteins. Here we report a novel compound targeting the …
[HTML][HTML] Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation
Glycosylation is a fundamental modification of proteins and membrane lipids. Toxins that
utilize glycans as their receptors have served as powerful tools to identify key players in …
utilize glycans as their receptors have served as powerful tools to identify key players in …
[PDF][PDF] Proteomic analysis identifies membrane proteins dependent on the ER membrane protein complex
The endoplasmic reticulum (ER) membrane protein complex (EMC) is a key contributor to
biogenesis and membrane integration of transmembrane proteins, but our understanding of its …
biogenesis and membrane integration of transmembrane proteins, but our understanding of its …
Anticancer gold (I)–phosphine complexes as potent autophagy-inducing agents
… Songhai Tian , Fung-Ming Siu , Steven CF Kui , Chun-Nam Lok and Chi-Ming Che * …
Tian, J. Lin, J. Zhou, X. …
Tian, J. Lin, J. Zhou, X. …
[HTML][HTML] Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants
Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides
difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty …
difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty …