User profiles for Sofian Al Shboul

Sofian Al Shboul

The Hashemite University
Verified email at hu.edu.jo
Cited by 62

Therapy-induced senescence as a component of tumor biology: evidence from clinical cancer

T Saleh, S Bloukh, M Hasan, S Al Shboul - Biochimica et Biophysica Acta …, 2023 - Elsevier
Therapy-Induced Senescence (TIS) is an established response to anticancer therapy in a
variety of cancer models. Ample evidence has characterized the triggers, hallmarks, and …

[HTML][HTML] NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy

S Al Shboul, M El-Sadoni, A Alhesa, N Abu Shahin… - Scientific Reports, 2023 - nature.com
Neoadjuvant chemotherapy (NAC) is a frequently utilized approach to treat locally advanced
breast cancer, but, unfortunately, a subset of tumors fails to undergo complete pathological …

A three-marker signature identifies senescence in human breast cancer exposed to neoadjuvant chemotherapy

M El-Sadoni, SA Shboul, A Alhesa, NA Shahin… - Cancer Chemotherapy …, 2023 - Springer
Purpose Despite the beneficial effects of chemotherapy, therapy-induced senescence (TIS)
manifests itself as an undesirable byproduct. Preclinical evidence suggests that tumor cells …

Can 3D bioprinting solve the mystery of senescence in cancer therapy?

S Al Shboul, VJ DeLuca, Y Al Dweiri, T Saleh - Ageing Research Reviews, 2022 - Elsevier
Tumor dormancy leading to cancer relapse is still a poorly understood mechanism. Several
cell states such as quiescence and diapause can explain the persistence of tumor cells in a …

[HTML][HTML] DIA-MS proteome analysis of formalin-fixed paraffin-embedded glioblastoma tissues

K Weke, S Kote, J Faktor, S Al Shboul… - Analytica Chimica …, 2022 - Elsevier
Developments in quantitative proteomics and use of data-independent acquisition (DIA)
methodology is enabling measurement of proteins of interest in biological samples. Currently, …

[HTML][HTML] Prevalence of SARS-COV-2 and other respiratory pathogens among a Jordanian subpopulation during Delta-to-Omicron transition: Winter 2021/2022

…, AA Tarifi, A Al Khawaldeh, H Al-Momani, S Al Shboul… - PLoS …, 2023 - journals.plos.org
Acute respiratory tract infections (ARTIs) during the winter months are associated with higher
morbidity and mortality compared to other seasons of the year, with children below five, …

[HTML][HTML] The expression of the senescence-associated biomarker Lamin B1 in human breast cancer

…, S Al Shboul, H Awad, S Bloukh, M Al-Balas… - Diagnostics, 2022 - mdpi.com
Senescence is a major response to cancer chemotherapy and has been linked to unfavorable
therapy outcomes. Lamin B1 is a component of the nuclear lamina that plays a pivotal role …

[HTML][HTML] Comparison of different digestion methods for proteomic analysis of isolated cells and FFPE tissue samples

…, B Vojtesek, TR Hupp, S Al Shboul… - Talanta, 2021 - Elsevier
Proteomics of human tissues and isolated cellular subpopulations create new opportunities
for therapy and monitoring of a patients’ treatment in the clinic. Important considerations in …

Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival

S Al Shboul, OE Curran, JA Alfaro… - Life Science …, 2021 - life-science-alliance.org
Better understanding of GBM signalling networks in-vivo would help develop more physiologically
relevant ex vivo models to support therapeutic discovery. A “functional proteomics” …

A conversation with ChatGPT on contentious issues in senescence and cancer research

AM Elshazly, U Shahin, S Al Shboul, DA Gewirtz… - Molecular …, 2024 - ASPET
Artificial Intelligence (AI) platforms such as Generative Pre-trained Transformer (ChatGPT)
have achieved a high degree of popularity amongst the scientific community due to their util-…