Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to
regulate the functional outcome of ubiquitylation. Here we report the discovery of a new …

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we
report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal …

SMAD transcription factors are key intracellular transducers of TGFβ cytokines. SMADs are
tightly regulated to ensure balanced cellular responses to TGFβ signals. Ubiquitylation has a …

Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous
squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK …

Members of the casein kinase 1 (CK1) family of serine-threonine protein kinases are implicated
in the regulation of many cellular processes, including the cell cycle, circadian rhythms, …

Maturation and translation of mRNA in eukaryotes requires the addition of the 7-methylguanosine
cap. In vertebrates, the cap methyltransferase, RNA guanine-7 methyltransferase (…

Allelic variations in CYP1B1 are reported to modulate the incidence of several types of
cancer. To provide a mechanistic basis for this association, we investigated the impact of …

Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases
such as cancer and neurodegeneration exhibiting defects in this process. Mitophagy is also …

The eight different types of ubiquitin (Ub) chains that can be formed play important roles in
diverse cellular processes. Linkage‐selective recognition of Ub chains by Ub‐binding domain …

The deubiquitylating enzyme OTUB1 is present in all tissues and targets many substrates, in
both the cytosol and nucleus. We found that casein kinase 2 (CK2) phosphorylated OTUB1 …