User profiles for Silvia Soddu
Silvia SodduRegina Elena Cancer Institute Verified email at ifo.gov.it Cited by 8195 |
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
Phosphorylation of p53 at Ser 46 was shown to regulate p53 apoptotic activity. Here we
demonstrate that homeodomain-interacting protein kinase-2 (HIPK2), a member of a novel …
demonstrate that homeodomain-interacting protein kinase-2 (HIPK2), a member of a novel …
p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis
I Cordone, S Masi, FR Mauro, S Soddu… - Blood, The Journal …, 1998 - ashpublications.org
We have analyzed by immunocytochemistry (ICC) the frequency of p53 protein expression
in 181 cases of B-cell chronic lymphocytic leukemia (CLL) followed at a single institution to …
in 181 cases of B-cell chronic lymphocytic leukemia (CLL) followed at a single institution to …
[PDF][PDF] MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
In response to DNA damage, p53 induces either cell-cycle arrest or apoptosis by differential
transcription of several target genes and through transcription-independent apoptotic …
transcription of several target genes and through transcription-independent apoptotic …
[HTML][HTML] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity
…, A Carrier, D Isnardon, B Cecchinelli, S Soddu… - Journal of Biological …, 2003 - ASBMB
The TP53INP1 gene encodes two protein isoforms, TP53INP1α and TP53INP1β, located into
the nucleus. Their synthesis is increased during cellular stress by p53-mediated activation …
the nucleus. Their synthesis is increased during cellular stress by p53-mediated activation …
[HTML][HTML] Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers
G Federici, S Soddu - Journal of Experimental & Clinical Cancer Research, 2020 - Springer
The promising expectations about personalized medicine have opened the path to routine
large-scale sequencing and increased the importance of genetic counseling for hereditary …
large-scale sequencing and increased the importance of genetic counseling for hereditary …
[HTML][HTML] NF-Y Mediates the Transcriptional Inhibition of thecyclin B1, cyclin B2, and cdc25CPromoters upon Induced G2 Arrest
…, K Krause, K Engeland, A Sacchi, S Soddu… - Journal of Biological …, 2001 - ASBMB
During normal cell cycles, the function of mitotic cyclin-cdk1 complexes, as well as of cdc25C
phosphatase, is required for G 2 phase progression. Accordingly, the G 2 arrest induced by …
phosphatase, is required for G 2 phase progression. Accordingly, the G 2 arrest induced by …
p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells
Alterations of the tumor suppressor gene p53 are uncommon in differentiated thyroid
neoplasia but are detected at high frequency in anaplastic thyroid carcinoma suggesting that …
neoplasia but are detected at high frequency in anaplastic thyroid carcinoma suggesting that …
p53 inhibits α6β4 integrin survival signaling by promoting the caspase 3–dependent cleavage of AKT/PKB
…, MJ Ribick, A Marchetti, R Falcioni, S Soddu… - The Journal of cell …, 1999 - rupress.org
Although the interaction of matrix proteins with integrins is known to initiate signaling pathways
that are essential for cell survival, a role for tumor suppressors in the regulation of these …
that are essential for cell survival, a role for tumor suppressors in the regulation of these …
[PDF][PDF] Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
Che-1 is a RNA polymerase II-binding protein involved in the transcription of E2F target genes
and induction of cell proliferation. Here we show that Che-1 contributes to DNA damage …
and induction of cell proliferation. Here we show that Che-1 contributes to DNA damage …
p53 regulates myogenesis by triggering the differentiation activity of pRb
The p53 oncosuppressor protein regulates cell cycle checkpoints and apoptosis, but
increasing evidence also indicates its involvement in differentiation and development. We had …
increasing evidence also indicates its involvement in differentiation and development. We had …