Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These different …

Stable isotope labeling by amino acids in cell culture (SILAC) has become a versatile tool
for quantitative, mass spectrometry (MS)-based proteomics. Here, we completely label mice …

Integrins are the major adhesion receptors of leukocytes and platelets. β 1 and β 2 integrin
function on leukocytes is crucial for a successful immune response and the platelet integrin α …

Recent studies suggest that, even within a single adipose depot, there may be distinct
subpopulations of adipocytes. To investigate this cellular heterogeneity, we have developed …

Integrin-mediated platelet adhesion and aggregation are essential for sealing injured blood
vessels and preventing blood loss, and excessive platelet aggregation can initiate arterial …

Obesity, diabetes, and metabolic syndrome result from complex interactions between genetic
and environmental factors, including the gut microbiota. To dissect these interactions, we …

Control of integrin activation is required for cell adhesion and ligand-induced signaling.
Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-…

Conditional gene targeting has been extensively used for in vivo analysis of gene function
in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of …

The three Kindlins are a novel family of focal adhesion proteins. The Kindlin-1 (URP1) gene
is mutated in Kindler syndrome, the first skin blistering disease affecting actin attachment in …

Sirt3 is an NAD + -dependent deacetylase that regulates mitochondrial function by targeting
metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal …