Induced pluripotent stem cells (iPSCs) undergo extensive nuclear reprogramming and are
generally indistinguishable from embryonic stem cells (ESCs) in their functional capacity and …

Following fertilization, totipotent cells undergo asymmetric cell divisions, resulting in three
distinct cell types in the late pre-implantation blastocyst: epiblast (Epi), primitive endoderm (PrE…

Vav1 functions as a signal transducer protein in the hematopoietic system, where it is
exclusively expressed. Vav1 was recently implicated in several human cancers, including lung, …

Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs)
or be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore …

Vav1 is a signal transducer that functions as a scaffold protein and a regulator of cytoskeleton
organization in the hematopoietic system, where it is exclusively expressed. Recently, …

The generation of induced pluripotent stem cells (iPSCs) and directly converted cells holds
great promise in regenerative medicine. However, after in-depth studies of the murine system…

Lysyl oxidase-like enzymes (LOXL) are expressed in various cancers. We analyzed the
expression of LOXL2, LOXL3, and LOXL4 in cancers involving the serosal cavities—breast …

The potential impact of Vav1 on human cancer was only recently acknowledged, as it is
detected as a mutant or an overexpressed gene in various cancers, including lung cancer. Vav1, …

Vav1 is normally and exclusively expressed in the hematopoietic system where it functions
as a specific GDP/GTP nucleotide exchange factor (GEF), firmly regulated by tyrosine …

We previously found LOXL4 to be alternatively spliced in an anatomic site-specific manner
in tumors involving the serosal cavities. LOXL4 splice variants were predominantly or …