[HTML][HTML] Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos

S Maenohara, M Unoki, H Toh, H Ohishi, J Sharif… - PLoS …, 2017 - journals.plos.org
The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed
during gametogenesis and preimplantation development. It was previously shown that …

Human papillomavirus genotype contribution to cervical cancer and precancer: Implications for screening and vaccination in Japan

…, T Iwata, K Yamamoto, Y Aoki, S Maenohara… - Cancer …, 2020 - Wiley Online Library
To obtain baseline data for cervical cancer prevention in Japan, we analyzed human
papillomavirus (HPV) data from 5045 Japanese women aged less than 40 years and diagnosed …

UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos

S Uemura, S Maenohara, K Inoue… - Life Science …, 2023 - life-science-alliance.org
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is a protein essential for the
maintenance of DNA methylation in somatic cells. However, UHRF1 is predominantly localized …

[HTML][HTML] The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer

…, L Cui, E Hori, M Kawakami, S Maenohara… - Journal of Biological …, 2024 - ASBMB
BHLHE40 is a basic helix-loop-helix transcription factor that is involved in multiple cell activities
including differentiation, cell cycle, and epithelial-to-mesenchymal transition. While there …

Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer

…, K Asanoma, M Kawakami, S Maenohara… - Cancer Gene …, 2023 - nature.com
Dysregulated G protein-coupled receptor signaling is involved in the formation and progression
of human cancers. The heterotrimeric G protein Gα 13 is highly expressed in various …

Development of novel tracers for sentinel node identification in cervical cancer

…, H Yahata, K Okugawa, S Maenohara… - Cancer …, 2023 - Wiley Online Library
Indocyanine green (ICG) with near‐infrared (NIR) fluorescence imaging is used for lymphatic
mapping. However, binding of ICG to blood proteins like serum albumin can shorten its …

Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer

…, K Hachisuga, N Yasutake, S Maenohara… - Gynecologic …, 2022 - Elsevier
Objective Sentinel node biopsy alone (SNB) reduces the postoperative complications of
pelvic lymphadenectomy, such as lymphedema and lymphangitis; however, the long-term …

Clinical Significance of Tumor Immune Microenvironment in Endometrial Endometrioid Carcinoma, Grade 1 With DNA Mismatch Repair Protein Loss

…, H Tomonobe, S Maenohara… - International Journal …, 2024 - journals.lww.com
The administration of immune checkpoint inhibitors (ICIs) is increasing in endometrial cancer,
especially in the mismatch repair (MMR)-deficient group. To prevent unnecessary immune-…

Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs

…, K Ariyoshi, K Taguchi, S Maenohara… - Journal of Obstetrics …, 2020 - Wiley Online Library
Aim Serous carcinoma of the uterine cervix (USCC) is a very rare malignant tumor, while this
histological subtype is common in the ovary, fallopian tube, uterine corpus and peritoneum. …

Decision-making for Subsequent Therapy for Patients With Recurrent or Advanced Endometrial Cancer Based on the Platinum-free Interval

…, E Hori, K Hachisuga, S Maenohara… - American journal of …, 2023 - journals.lww.com
Objective: The aim of this study was to evaluate the progression-free survival (PFS) and
overall response rate (ORR) of patients with recurrent endometrial cancer (REC) or advanced …