[HTML][HTML] Physiological and pathological phosphorylation of tau by Cdk5
T Kimura, K Ishiguro, S Hisanaga - Frontiers in molecular …, 2014 - frontiersin.org
Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological
events in Alzheimer’s disease (AD) and other related neurodegenerative diseases, …
events in Alzheimer’s disease (AD) and other related neurodegenerative diseases, …
[HTML][HTML] Phospho-tau bar code: Analysis of phosphoisotypes of tau and its application to tauopathy
…, G Sharma, K Ishiguro, S Hisanaga - Frontiers in …, 2018 - frontiersin.org
Tau is a microtubule-associated protein which regulates the assembly and stability of
microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (…
microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (…
Regulation and role of cyclin‐dependent kinase activity in neuronal survival and death
S Hisanaga, R Endo - Journal of neurochemistry, 2010 - Wiley Online Library
Regulation and role of cyclin‐dependent kinase activity in neuronal survival and death -
Hisanaga - 2010 - Journal of Neurochemistry - Wiley Online Library … Shin-ichi Hisanaga …
Hisanaga - 2010 - Journal of Neurochemistry - Wiley Online Library … Shin-ichi Hisanaga …
[HTML][HTML] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
S Taniguchi, N Suzuki, M Masuda, S Hisanaga… - Journal of Biological …, 2005 - ASBMB
Tau protein is the major component of the intraneuronal filamentous inclusions that constitute
defining neuropathological characteristics of Alzheimer's disease and other tauopathies. …
defining neuropathological characteristics of Alzheimer's disease and other tauopathies. …
[HTML][HTML] Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25
…, R Onuki, K Ishiguro, T Kishimoto, S Hisanaga - Journal of Biological …, 2000 - ASBMB
Cyclin-dependent kinase 5 (CDK5) is a unique CDK, the activity of which can be detected in
postmitotic neurons. To date, CDK5 purified from mammalian brains has always been …
postmitotic neurons. To date, CDK5 purified from mammalian brains has always been …
Small molecule inhibitors of α-synuclein filament assembly
…, T Oikawa, T Nonaka, T Iwatsubo, S Hisanaga… - Biochemistry, 2006 - ACS Publications
α-Synuclein is the major component of the filamentous inclusions that constitute defining
characteristics of Parkinson's disease and other α-synucleinopathies. Here we have tested 79 …
characteristics of Parkinson's disease and other α-synucleinopathies. Here we have tested 79 …
Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease
…, Y Toyoshima, M Hasegawa, S Hisanaga - Journal of …, 2012 - Soc Neuroscience
The microtubule-associated protein Tau is a major component of the neurofibrillary tangles
that serve as a neuropathological hallmark of Alzheimer's disease. Tau is a substrate for …
that serve as a neuropathological hallmark of Alzheimer's disease. Tau is a substrate for …
Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule …
K Ookata, S Hisanaga, JC Bulinski… - The Journal of cell …, 1995 - rupress.org
We previously demonstrated (Ookata et al., 1992, 1993) that the p34cdc2/cyclin B complex
associates with microtubules in the mitotic spindle and premeiotic aster in starfish oocytes, …
associates with microtubules in the mitotic spindle and premeiotic aster in starfish oocytes, …
Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing
S Hisanaga, N Hirokawa - Journal of molecular biology, 1988 - Elsevier
The structure of the peripheral domains of neurofilaments (NFs) was revealed by rotary
shadowing electron microscopy. NFs were isolated from bovine spinal cords by Sepharose CL-…
shadowing electron microscopy. NFs were isolated from bovine spinal cords by Sepharose CL-…
[HTML][HTML] Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
…, E Buratti, FE Baralle, H Akiyama, S Hisanaga… - FEBS letters, 2008 - Elsevier
A monoclonal antibody specific for phosphoserines 409 and 410 of TDP-43 (mAb pS409/410)
has been produced. It strongly stained TDP-43-positive inclusions in brain of patients with …
has been produced. It strongly stained TDP-43-positive inclusions in brain of patients with …