CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base
composition and high density of CpG dinucleotides 1 , 2 . Most human gene promoters are …

MeCP2 is a nuclear protein with an affinity for methylated DNA that can recruit histone
deacetylases. Deficiency or excess of MeCP2 causes severe neurological problems, suggesting …

CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of most
genes and often lack DNA methylation. Querying their apparent importance, the number of …

Human and mouse genomes contain a similar number of CpG islands (CGIs), which are
discrete CpG-rich DNA sequences associated with transcription start sites. In both species, ∼50…

Trimethylation of histone H3 Lys 4 (H3K4me3) is a mark of active and poised promoters.
The Set1 complex is responsible for most somatic H3K4me3 and contains the conserved …

During transcription, the nascent RNA can invade the DNA template, forming extended RNA-DNA
duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase …

Whether gene repositioning to the nuclear periphery during differentiation adds another
layer of regulation to gene expression remains controversial. Here, we resolve this by …

Background Nrd1 and Nab3 are essential sequence-specific yeast RNA binding proteins
that function as a heterodimer in the processing and degradation of diverse classes of RNAs. …

Background TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM)
family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. …

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several
neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the …