Tau protein provides DNA with thermodynamic and structural features which are similar to those found in histone-DNA complex
S Camero, MJ Benítez, A Barrantes… - Journal of …, 2014 - content.iospress.com
Tau protein has been proposed as a trigger of Alzheimer's disease once it is hyperphosphorylated.
However, the role that native tau forms play inside the neuronal nucleus remains …
However, the role that native tau forms play inside the neuronal nucleus remains …
[HTML][HTML] Thermodynamics of the interaction between Alzheimer's disease related tau protein and DNA
S Camero, MJ Benítez, R Cuadros, F Hernandez… - PLoS …, 2014 - journals.plos.org
Tau hyperphosphorylation can be considered as one of the hallmarks of Alzheimer's disease
and other tauophaties. Besides its well-known role as a microtubule associated protein, …
and other tauophaties. Besides its well-known role as a microtubule associated protein, …
Specific binding of DNA to aggregated forms of Alzheimer's disease amyloid peptides
Anomalous protein aggregation is closely associated to age-related mental illness.
Extraneuronal plaques, mainly composed of aggregated amyloid peptides, are considered as …
Extraneuronal plaques, mainly composed of aggregated amyloid peptides, are considered as …
The RBS1 domain of Gemin5 is intrinsically unstructured and interacts with RNA through conserved Arg and aromatic residues
A Embarc-Buh, R Francisco-Velilla, S Camero… - RNA biology, 2021 - Taylor & Francis
Gemin5 is a multifaceted RNA-binding protein that comprises distinct structural domains,
including a WD40 and TPR-like for which the X-ray structure is known. In addition, the protein …
including a WD40 and TPR-like for which the X-ray structure is known. In addition, the protein …
Structural basis of Nrd1–Nab3 heterodimerization
…, S Martínez-Lumbreras, S Camero… - Life science …, 2022 - life-science-alliance.org
Heterodimerization of RNA binding proteins Nrd1 and Nab3 is essential to communicate the
RNA recognition in the nascent transcript with the Nrd1 recognition of the Ser 5 -…
RNA recognition in the nascent transcript with the Nrd1 recognition of the Ser 5 -…
Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death.
This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 …
This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 …
Alzheimer's disease amyloid peptides interact with DNA, as proved by surface plasmon resonance
A Barrantes, S Camero, A Garcia-Lucas… - Current Alzheimer …, 2012 - ingentaconnect.com
According to the amyloid hypothesis, abnormal processing of the β-amyloid precursor protein
in Alzheimer's disease patients increases the production of β-amyloid toxic peptides, which…
in Alzheimer's disease patients increases the production of β-amyloid toxic peptides, which…
Anomalous Protein–DNA Interactions Behind Neurological Disorders
S Camero, MJ Benítez, JS Jiménez - Advances in protein chemistry and …, 2013 - Elsevier
Aggregation, nuclear location, and nucleic acid interaction are common features shared by
a number of proteins related to neurodegenerative diseases, including Alzheimer’s disease, …
a number of proteins related to neurodegenerative diseases, including Alzheimer’s disease, …
[HTML][HTML] eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly
…, S Martínez-Lumbreras, N Sibille, S Camero… - Frontiers in molecular …, 2022 - frontiersin.org
Yeast eIF4G1 interacts with RNA binding proteins (RBPs) like Pab1 and Pub1 affecting its
function in translation initiation and stress granules formation. We present an NMR and SAXS …
function in translation initiation and stress granules formation. We present an NMR and SAXS …
Multivalent interactions between eIF4G1, Pub1 and Pab1 drive the formation of protein condensates
…, S Martínez-Lumbreras, N Sibille, S Camero… - bioRxiv, 2020 - biorxiv.org
Yeast eIF4G1 interacts with RNA binding proteins (RBPs) like Pab1 and Pub1 affecting its
function in translation initiation and stress granules formation. We present an NMR and SAXS …
function in translation initiation and stress granules formation. We present an NMR and SAXS …