Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for
the treatment of homologous recombination (HR)-deficient cancers. Despite the success of …

Oncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression,
causes genomic instability and has been linked to tumorigenesis. To survive high levels of …

(Cancer Cell 33, 1078–1093. e1–e12; June 11, 2018) In the originally published version of
this article, the red section (> 20%) of the pie chart ‘‘Triple-negative breast cancers’’in Figure …

Replication stress entails the improper progression of DNA replication. In cancer cells,
including breast cancer cells, an important cause of replication stress is oncogene activation. …

Oncogene-induced replication stress characterizes many aggressive cancers. Several
treatments are being developed that target replication stress, however, identification of tumors …

The brain cancer medulloblastoma consists of different transcriptional subgroups. To
characterize medulloblastoma at the phosphoprotein-signaling level, we performed high-…

Genomically instable cancers are characterized by progressive loss and gain of chromosomal
fragments, and the acquisition of complex genomic rearrangements. Such cancers, …

Reproduction depends on successful cell division, which is coordinated in the cell cycle.
Especially in the context of multicellular organisms, proper control of cell cycle initiation and …

Most tumors lack the G1/S phase checkpoint and are insensitive to antigrowth signals. Loss
of G1/S control can severely perturb DNA replication as revealed by slow replication fork …

Genomic instability is a hallmark of cancer for which an important cause is the DNA damage
generated by oncogene-induced replication stress (RS). Genomically instable cancers …