Regulation of innate immune responses in the brain

S Rivest - Nature Reviews Immunology, 2009 - nature.com
Microglial cells are the main innate immune cells of the complex cellular structure of the
brain. These cells respond quickly to pathogens and injury, accumulate in regions of …

Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain

…, JS Mogil, Y De Koninck, S Rivest - Journal of …, 2007 - Soc Neuroscience
Neuropathic pain resulting from damage to or dysfunction of peripheral nerves is not well
understood and difficult to treat. Although CNS hyperexcitability is a critical component, recent …

[PDF][PDF] Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

AR Simard, D Soulet, G Gowing, JP Julien, S Rivest - Neuron, 2006 - cell.com
Microglia are the immune cells of the brain. Here we show a massive infiltration of highly
ramified and elongated microglia within the core of amyloid plaques in transgenic mouse …

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

…, C Veltkamp, H Doerr, C Sommer, S Rivest… - Nature medicine, 2009 - nature.com
Systemic and local inflammatory processes have a key, mainly detrimental role in the
pathophysiology of ischemic stroke. Currently, little is known about endogenous counterregulatory …

Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms

C Rivier, S Rivest - Biology of reproduction, 1991 - academic.oup.com
This article reviews the mechanisms believed to mediate stress-induced inhibition of
reproductive functions and the anatomical sites at which these effects take place. Particular …

Innate immunity: the missing link in neuroprotection and neurodegeneration?

MD Nguyen, JP Julien, S Rivest - Nature Reviews Neuroscience, 2002 - nature.com
Innate immunity was previously thought to be a nonspecific immunological programme that
was engaged by peripheral organs to maintain homeostasis after stress and injury. Emerging …

Toll‐like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram‐negative bacterial cell wall components

N LAFLAMME, S RIVEST - The FASEB Journal, 2001 - Wiley Online Library
The recent characterization of human homologues of Toll may be the missing link for the
transduction events leading to NF‐κB activity and proinflammatory gene transcription during …

Expression and neuropeptidergic characterization of estrogen receptors (ERα and ERβ) throughout the rat brain: anatomical evidence of distinct roles of each subtype

…, RE Nappi, G Drolet, C Labrie, S Rivest - Journal of …, 1998 - Wiley Online Library
The recent cloning of a second estrogen receptor (ER) provided a new tool to investigate
and clarify how estrogens are capable of communicating with the brain and influence gene …

Molecular insights on the cerebral innate immune system

S Rivest - Brain, behavior, and immunity, 2003 - Elsevier
All species need an immediate reply to the microbial pathogens that is part of an effective
immune response and is essential for the survival of most organisms. This reply is known as …

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

…, VW Yong, PK Stys, MÈ Tremblay, S Rivest - Journal of Experimental …, 2015 - rupress.org
An imbalance between remyelinating and demyelinating rates underlies degenerative
processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic strategy …