TCRαβ thymocytes differentiate into either CD8αβ + cytotoxic T lymphocytes or CD4 + helper
T cells. This functional dichotomy is controlled by key transcription factors, including the …

CD4 and the transcription factor ThPOK are essential for the differentiation of major
histocompatibility complex class II–restricted thymocytes into the helper T cell lineage; their genes (…

Mouse CD4 + CD8 + double-positive (DP) thymocytes differentiate into CD4 + helper-lineage
cells upon expression of the transcription factor Th-POK but commit to the CD8 + cytotoxic …

Interferon γ (IFNγ) is the hallmark cytokine produced by T helper type 1 (Th1) cells, whereas
interleukin (IL)-4 is the hallmark cytokine produced by Th2 cells. Although previous studies …

T cell receptor (TCR) signaling by MHC class I and II induces thymocytes to acquire cytotoxic
and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively. …

We isolated two mouse cDNA clones which show significant similarities with human
angiotensin-converting enzyme-related carboxypeptidase (ACE2). The cDNAs were 2746 and 1995 …

The transcription factor Runx1 is a pivotal regulator of definitive hematopoiesis in mouse
ontogeny. Vertebrate Runx1 is transcribed from 2 promoters, the distal P1 and proximal P2, …

T-lineage committed precursor thymocytes are screened by a fate-determination process
mediated via T cell receptor (TCR) signals for differentiation into distinct lineages. However, it …

CD4 + helper and CD8 + cytotoxic T cells differentiate from common precursors in the
thymus after T‐cell receptor (TCR)‐mediated selection. Commitment to the helper lineage …

An intronic silencer, S4, in the Cd4 gene has been shown to be responsible for the helper-lineage-specific
expression of CD4; S4 requires Runx complex binding to exert its silencer …