Extracellular vesicles are highly transmissible and play critical roles in the propagation of tau
pathology, although the underlying mechanism remains elusive. Here, for the first time, we …

In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …

… Gendelman provided brain samples; Satoshi Muraoka and Tsuneya Ikezu wrote the paper;
Satoshi Muraoka, Annina M.DeLeo, Manveen K. Sethi, Seiko Ikezu, Jina Ko, Zijian Yang, …

The Chromosome-Centric Human Proteome Project (C-HPP) is an international effort for
creating an annotated proteomic catalog for each chromosome. The first step of the C-HPP …

Pathological hallmarks of Alzheimer’s disease (AD) are deposits of amyloid beta (Aβ) and
hyper-phosphorylated tau aggregates in brain plaques. Recent studies have highlighted the …

Protein phosphorylation is a key mechanism of cellular signaling pathways and aberrant
phosphorylation has been implicated in a number of human diseases. Thus, approaches in …

In this work, we focus on the front and back interfaces of absorber, which, along with the
crystalline quality of the absorber, are definitely important in obtaining high efficiency for …

Recent advances in quantitative proteomic technology have enabled the large-scale
validation of biomarkers. We here performed a quantitative proteomic analysis of membrane …

Extracellular vesicles (EVs) are ubiquitously secreted by almost all tissues and carry many
cargoes, including proteins, RNAs, and lipids, which are related to various biological …

Extracellular vesicle (EV) is a unified terminology of membrane-enclosed vesicular species
ubiquitously secreted by almost every cell type and present in all body fluids. They carry a …