Repair of bulky DNA adducts by the nucleotide excision repair (NER) pathway is one of the
more versatile DNA repair pathways for the removal of DNA lesions. There are two subsets of …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Targeting uncontrolled cell proliferation and resistance to DNA-damaging chemotherapeutics
with a single agent has significant potential in cancer treatment. Replication protein A (RPA…

The energy-dissipating capacity of brown adipose tissue through thermogenesis can be
targeted to improve energy balance. Mammalian 5′-AMP-activated protein kinase, a key …

Human DJ‐1 is a cytoprotective protein whose absence causes Parkinson's disease and is
also associated with other diseases. DJ‐1 has an established role as a redox‐regulated …

We investigated potential mechanisms by which elevated glucose may promote genomic
instability. Gene expression studies, protein measurements, mass spectroscopic analyses, and …

Extracellular vesicles (EVs) encompass a diverse set of membrane-derived particles released
from cells and are found in numerous biological matrices and the extracellular space. …

The obesity rate in the United States is 42.4% and has become a national epidemic. Obesity
is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age, …

More precise identification and treatment monitoring of prediabetic/diabetic individuals will
require additional biomarkers to complement existing diagnostic tests. Candidates include …

<p>More than 30% of patients with type 1 diabetes develop diabetic kidney disease (DKD),
which significantly increases mortality risk. The Diabetes Control and Complications Trial (…