User profiles for Sangappa B Chadchan

Sangappa Chadchan

Scientist, Dept. of Immunology, St. Jude Children's Research Hospital
Verified email at stjude.org
Cited by 744

[HTML][HTML] Female reproductive dysfunctions and the gut microbiota

SB Chadchan, V Singh… - Journal of molecular …, 2022 - jme.bioscientifica.com
The gut microbiome is considered an endocrine organ that can influence distant organs and
associated biological pathways. Recent advances suggest that gut microbial homeostasis is …

Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota

SB Chadchan, M Cheng, LA Parnell, Y Yin… - Human …, 2019 - academic.oup.com
STUDY QUESTION Does altering gut microbiota with antibiotic treatment have any impact
on endometriosis progression? SUMMARY ANSWER Antibiotic therapy reduces …

The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization

SB Chadchan, P Popli, VK Maurya… - Biology of …, 2021 - academic.oup.com
The coronavirus disease 2019 (COVID-19) first appeared in December 2019 and rapidly
spread throughout the world. The SARS-CoV-2 virus enters the host cells by binding to the …

[HTML][HTML] Gut microbiota and microbiota-derived metabolites promotes endometriosis

SB Chadchan, SK Naik, P Popli, C Talwar… - Cell Death …, 2023 - nature.com
Endometriosis is a pathological condition of the female reproductive tract characterized by the
existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the …

Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis

SB Chadchan, P Popli, CR Ambati… - Life science …, 2021 - life-science-alliance.org
Worldwide, ∼196 million are afflicted with endometriosis, a painful disease in which
endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories on the …

[HTML][HTML] Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation

P Popli, MM Richters, SB Chadchan, TH Kim… - Cell death & …, 2020 - nature.com
Although endometrial cancer is the most common cancer of the female reproductive tract,
we have little understanding of what controls endometrial cancer beyond the transcriptional …

The Autophagy Gene Atg16L1 is Necessary for Endometrial Decidualization

AK Oestreich, SB Chadchan, P Popli… - …, 2020 - academic.oup.com
Uterine receptivity is critical for establishing and maintaining pregnancy. For the endometrium
to become receptive, stromal cells must differentiate into decidual cells capable of …

Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization

AJ Camden, MM Szwarc, SB Chadchan… - MHR: Basic science …, 2017 - academic.oup.com
… (B) Greb1 transcript levels in uteri from ovariectomized mice treated with vehicle or
progesterone (P4) (1 mg) for 6, 12 or 24 h. Results represent the mean ± SE; n = 3 mice/group. (C) …

[HTML][HTML] Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization

Y Yin, ME Haller, SB Chadchan, R Kommagani, L Ma - JCI insight, 2021 - ncbi.nlm.nih.gov
Retinoic acid (RA) signaling has long been speculated to regulate embryo implantation,
because many enzymes and proteins responsible for maintaining RA homeostasis and …

Isolation of human endometrial stromal cells for in vitro decidualization

SA Michalski, SB Chadchan, ES Jungheim… - JoVE (Journal of …, 2018 - jove.com
The differentiation of human endometrial stromal cells (HESC) from fibroblast-like appearance
into secretory decidua is a transformation required for embryo implantation into the …