More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of
severe malaria is still not well understood. The majority of malaria cases are caused by …

Cerebral malaria (CM) is a major cause of mortality in African children and the mechanisms
underlying its development, namely how malaria-infected erythrocytes (IEs) cause disease …

Brain lesions of cerebral malaria (CM) are characterized by a sequestration of Plasmodium
falciparum-parasitized red blood cells (PRBC) and platelets within brain microvessels, as …

The mechanisms underlying the rapidly reversible brain swelling described in patients with
cerebral malaria (CM) are unknown. Using a 1.5-Tesla (T) magnetic resonance imaging (MRI…

Cerebral malaria (CM) is caused by the binding of Plasmodium falciparum–infected
erythrocytes (IEs) to the brain microvasculature, leading to inflammation, vessel occlusion, and …

Platelets have recently been shown to accumulate in brain microvessels of patients with
cerebral malaria and to modulate the binding of Plasmodium falciparum-infected red cells to …

Background Cerebral malaria is a common presentation of severe Plasmodium falciparum
infection and remains an important cause of death in the tropics. Key aspects of its …

Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed blood …

Plasmodium falciparum gametocytes, the sexual stage responsible for malaria parasite
transmission from humans to mosquitoes, are key targets for malaria elimination. Immature …

Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum
infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this …