Adenine base editing (ABE) enables enzymatic conversion from AT into GC base pairs. ABE
holds promise for clinical application, as it does not depend on the introduction of double-…

Background CFTR function measurements in intestinal organoids may help to better
characterise individual disease expression in F508del homozygous people. Our objective was to …

Cystic fibrosis is caused by genetic defects that impair the CFTR channel in airway epithelial
cells. These defects may be overcome by specific CFTR modulating drugs, for which the …

Contact hypersensitivity responsiveness to dinitrofluorobenzene is depressed in mice that
are sensitized through skin sites exposed to ultraviolet (UV) radiation. Local impairment of …

The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected
in the monogenic disorder cystic fibrosis (CF). Recent studies have uncovered that nasal …

Considerable heterogeneity among training-induced effects is observed in patients with
cystic fibrosis (CF). We previously showed that longitudinal changes in exercise capacity in …

Background Cystic fibrosis is a rare recessive monogenic disease caused by loss-of-function
mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. …

The loss of spleen may lead to fatal bacterial infections. To prevent this, splenic autotransplantation
has been performed in humans and experimental animals. However, there is still …

DNA analysis using STR amplification become increasingly sensitive permitting the use of
minutes quantities of DNA transferred through skin contact. However, in such case, the …

The opioidergic innervation of the mammalian spleen and possible species differences
were investigated. Light-microscopic immunohistochemistry revealed that splenic nerves of …