OBJECTIVE The pathogenesis of diabetic nephropathy is complex and involves activation of
multiple pathways leading to kidney damage. An important role for altered lipid metabolism …

… The signal transduction of TGF-β is regulated via a heteromeric complex of type I and type
II TGF-β receptors. The type II receptor is the primary binding protein for ligands and is the …

Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR
agonists have been shown to limit the cellular cholesterol content by inducing reverse …

… The upper band is the expression of unspliced forms of XBP ‐1 m RNA (u XBP ‐1) and
the lower is the expression of spliced forms of XBP ‐1 m RNA (s XBP ‐1). ***P<0.001. ALP …

… Activation of FXR is reported to lead to both pro- and anti-atherosclerotic effects. In the … That
pharmacological FXR activation specifically affects this cholesterol-rich HDL 2 subclass is a …

… We hypothesized that dual activation of FXR and TGR5 is effective in the prevention of
atherosclerotic formation. In this study, we examined the pharmacologic effects of simultaneous …

The accumulation of lipids, including cholesterol, in the arterial wall plays a key role in the
pathogenesis of atherosclerosis. Although several advances have been made in the detection …

… In this study, we examined which nuclear receptor(s) is involved in the development of
vascular calcification, a major complication in subjects with CKD and a strong predictor of …

… Oxidized low‐density lipoprotein (LDL) is present in atherosclerotic and calcified plaques
and is thought to play an important role in the development of atherosclerosis and vascular …

… is common in VSMCs of murine models of vascular calcification. The reduction of klotho, an
aging-related protein, is … of SCD induced by klotho deficiency is a major event in vascular …