An inflammatory process in the central nervous system (CNS) is believed to play an important
role in the pathway leading to neuronal cell death in a number of neurodegenerative …

Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

Mesenchymal stem cells (MSCs), cultured ex vivo, recently were shown to be able to migrate
into sites of brain injuries when transplanted systemically or locally, suggesting that MSCs …

Background Hypoxia induces microglial activation which causes damage to the developing
brain. Microglia derived inflammatory mediators may contribute to this process. Toll-like …

Multi-protein complexes, termed “inflammasomes,” are known to contribute to neuronal cell
death and brain injury following ischemic stroke. Ischemic stroke increases the expression …

The release of proinflammatory mediators such as tumor necrosis factor‐α (TNF‐α) and
nitric oxide by microglia has been implicated in neurotoxicity in chronic neurodegenerative …

Metallothioneins (MTs) belong to a family of cysteine-rich, metal-binding intracellular proteins,
which have been linked with cell proliferation. In this study, expression levels of the 8 …

Cerebral ischemia leads to neuroinflammation and activation of microglia which further
contribute to stroke pathology. Understanding regulation of microglial activation will aid in the …

The significance of microglia and astrocytes in neural development, in maintaining synaptic
connections and homeostasis in the healthy brain is well established. Microglia are dynamic …

Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia
(higher level of glucose in the blood than usual). DM and its complications can lead to …