Higher eukaryotes typically contain many different cell types, displaying different cellular
functions that are influenced by biotic and abiotic cues. The different functions are characterized …

Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be
directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy …

Kidney tumours are among the most common solid tumours in children, comprising distinct
subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-…

This work describes the culture of organoids derived from HNSCC and corresponding
normal epithelium. These tumoroids recapitulate the disease genetically, histologically, and …

Cervical cancer is a common gynecological malignancy often caused by high-risk human
papillomavirus. There is a paucity of human-derived culture systems to study the cervical …

Mutation accumulation during life can contribute to hematopoietic dysfunction; however, the
underlying dynamics are unknown. Somatic mutations in blood progenitors can provide …

Adenine base editing (ABE) enables enzymatic conversion from AT into GC base pairs. ABE
holds promise for clinical application, as it does not depend on the introduction of double-…

Prime editing is a recent genome editing technology using fusion proteins of Cas9-nickase
and reverse transcriptase, that holds promise to correct the vast majority of genetic defects. …

Background While most cells in multicellular organisms carry the same genetic information,
in each cell type only a subset of genes is being transcribed. Such differentiation in gene …

The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in
cholangiocarcinoma. BAP1 has many proposed molecular targets, while its Drosophila homolog is …