[HTML][HTML] Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
Background Poncirin is flavanone derivative (isolated from Poncirus trifoliata) with known
pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-…
pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-…
[HTML][HTML] Metabolic regulation of glial phenotypes: implications in neuron–glia interactions and neurological disorders
Glial cells are multifunctional, non-neuronal components of the central nervous system with
diverse phenotypes that have gained much attention for their close involvement in …
diverse phenotypes that have gained much attention for their close involvement in …
Antinociceptive properties of 25‐methoxy hispidol A, a triterpinoid isolated from Poncirus trifoliata (Rutaceae) through inhibition of NF‐κB signalling in mice
A Khan, MZ Ullah, R Afridi, H Rasheed… - Phytotherapy …, 2019 - Wiley Online Library
The 25‐methoxy hispidol A (25‐MHA) is a triterpenoid, isolated from the immature fruit of
Poncirus trifoliata (Rutaceae). The pretreatment with 25‐MHA markedly (p < 0.001) attenuated …
Poncirus trifoliata (Rutaceae). The pretreatment with 25‐MHA markedly (p < 0.001) attenuated …
Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting
Understanding the pathophysiological mechanisms of neuropsychiatric disorders has been
a challenging quest for neurobiologists. Recent years have witnessed enormous …
a challenging quest for neurobiologists. Recent years have witnessed enormous …
[HTML][HTML] Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases
Glial cells are the most abundant cells of the brain, outnumbering neurons. These multifunctional
cells are crucial for maintaining brain homeostasis by providing trophic and nutritional …
cells are crucial for maintaining brain homeostasis by providing trophic and nutritional …
[HTML][HTML] Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-κB and Nrf2 signaling
The present study investigates the possible anti-nociceptive effect of intraperitoneal (ip)
honokiol: a phenolic compound originally isolated from Magnolia officinalis, in acute and chronic …
honokiol: a phenolic compound originally isolated from Magnolia officinalis, in acute and chronic …
[HTML][HTML] Microglia gone awry: linking immunometabolism to neurodegeneration
Age-related chronic inflammatory activation of microglia and their dysfunction are observed
in many neurodegenerative diseases, and the potential contributions of these dysfunctional …
in many neurodegenerative diseases, and the potential contributions of these dysfunctional …
Gamma subunit of complement component 8 is a neuroinflammation inhibitor
The complement system is part of the innate immune system that comprises several small
proteins activated by sequential cleavages. The majority of these complement components, …
proteins activated by sequential cleavages. The majority of these complement components, …
[HTML][HTML] Neuroinflammatory basis of depression: learning from experimental models
R Afridi, K Suk - Frontiers in cellular neuroscience, 2021 - frontiersin.org
The neuroinflammatory basis of depression encompasses the detrimental role of otherwise
supportive non-neuronal cells and neuroinflammation in hampering neuronal function, …
supportive non-neuronal cells and neuroinflammation in hampering neuronal function, …
Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators
MZ Ullah, AU Khan, R Afridi, H Rasheed… - International …, 2018 - Elsevier
In the current study, the puerarin was investigated for both acute Carrageenan and chronic
CFA-induced inflammatory pain models. The Puerarin treatment significantly attenuated (P < …
CFA-induced inflammatory pain models. The Puerarin treatment significantly attenuated (P < …