Microglia have critical roles not only in neural development and homeostasis, but also in
neurodegenerative and neuroinflammatory diseases of the central nervous system 1 , 2 , 3 – 4 . …

The extent of microglial heterogeneity in humans remains a central yet poorly explored question
in light of the development of therapies targeting this cell type. Here, we investigate the …

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia (MG)
and CNS-associated macrophages (CAMs). During experimental autoimmune …

J. Neurochem. (2012) 120, 461–472. Abstract Activation of microglia, the resident macrophages
of the brain, around the amyloid plaques is a key hallmark of Alzheimer’s disease (AD). …

Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

All tissue-resident macrophages of the central nervous system (CNS)—including parenchymal
microglia, as well as CNS-associated macrophages (CAMs 1 ) such as meningeal and …

Despite recent advances in cancer immunotherapy, certain tumor types, such as
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor …

The nervous and immune systems have evolved in parallel from the early bilaterians, in which
innate immunity and a central nervous system (CNS) coexisted for the first time, to jawed …

Microglia and central nervous system (CNS)-associated macrophages (CAMs), such as
perivascular and meningeal macrophages, are implicated in virtually all diseases of the CNS. …