User profiles for Roberto H Herai

Roberto H. Herai

PUCPR
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Cited by 2157

[PDF][PDF] Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation

…, L Tejwani, CA Trujillo, PD Negraes, RH Herai… - Cell stem cell, 2017 - cell.com
Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic
acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated …

Differential L1 regulation in pluripotent stem cells of humans and apes

…, JL Nathanson, ACM Paquola, KN Desai, RH Herai… - Nature, 2013 - nature.com
Identifying cellular and molecular differences between human and non-human primates (NHPs)
is essential to the basic understanding of the evolution and diversity of our own species. …

Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment

…, S Preissl, A Wang, PD Negraes, RA Szeto, RH Herai… - Science, 2021 - science.org
INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present. …

A human neurodevelopmental model for Williams syndrome

…, CA Trujillo, BC Freitas, B Hrvoj-Mihic, RH Herai… - Nature, 2016 - nature.com
Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon
hypersociability and a mosaic of retained and compromised linguistic and cognitive …

Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

…, J Lux, A Acab, CA Trujillo, RH Herai… - Proceedings of the …, 2016 - National Acad Sciences
Probing a wide range of cellular phenotypes in neurodevelopmental disorders using patient-derived
neural progenitor cells (NPCs) can be facilitated by 3D assays, as 2D systems …

[HTML][HTML] SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

…, C Snethlage, JW Adams, SH Avansini, RH Herai… - PLoS …, 2022 - journals.plos.org
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent
of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the …

[HTML][HTML] Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy

…, J Truong, R Szeto, T Tran, RH Herai… - Molecular …, 2021 - nature.com
Early-onset epileptic encephalopathies are severe disorders often associated with specific
genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a …

[HTML][HTML] Blocking Zika virus vertical transmission

…, MJ Kolar, S Montefusco, SC Rosenberg, RH Herai… - Scientific reports, 2018 - nature.com
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of
congenital malformations. Although recent efforts have focused on vaccine development, …

[HTML][HTML] Impact of alcohol exposure on neural development and network formation in human cortical organoids

…, J Truong, T Tran, RA Szeto, BS Guerra, RH Herai… - Molecular …, 2023 - nature.com
Prenatal alcohol exposure is the foremost preventable etiology of intellectual disability and
leads to a collection of diagnoses known as Fetal Alcohol Spectrum Disorders (FASD). …

Genetic variations on SETD5 underlying autistic conditions

…, A Ferrasa, D Phan, RH Herai… - Developmental …, 2018 - Wiley Online Library
The prevalence of autism spectrum disorders (ASD) and the number of identified ASD‐related
genes have increased in recent years. The SETD5 gene encodes a SET‐containing‐…