User profiles for Roberto H Herai
Roberto H. HeraiPUCPR Verified email at pucpr.br Cited by 2157 |
[PDF][PDF] Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation
Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic
acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated …
acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated …
Differential L1 regulation in pluripotent stem cells of humans and apes
…, JL Nathanson, ACM Paquola, KN Desai, RH Herai… - Nature, 2013 - nature.com
Identifying cellular and molecular differences between human and non-human primates (NHPs)
is essential to the basic understanding of the evolution and diversity of our own species. …
is essential to the basic understanding of the evolution and diversity of our own species. …
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present. …
indicate that many hominin lineage branches arose, but only one survived to the present. …
A human neurodevelopmental model for Williams syndrome
Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon
hypersociability and a mosaic of retained and compromised linguistic and cognitive …
hypersociability and a mosaic of retained and compromised linguistic and cognitive …
Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction
Probing a wide range of cellular phenotypes in neurodevelopmental disorders using patient-derived
neural progenitor cells (NPCs) can be facilitated by 3D assays, as 2D systems …
neural progenitor cells (NPCs) can be facilitated by 3D assays, as 2D systems …
[HTML][HTML] SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent
of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the …
of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the …
[HTML][HTML] Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy
…, J Truong, R Szeto, T Tran, RH Herai… - Molecular …, 2021 - nature.com
Early-onset epileptic encephalopathies are severe disorders often associated with specific
genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a …
genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a …
[HTML][HTML] Blocking Zika virus vertical transmission
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of
congenital malformations. Although recent efforts have focused on vaccine development, …
congenital malformations. Although recent efforts have focused on vaccine development, …
[HTML][HTML] Impact of alcohol exposure on neural development and network formation in human cortical organoids
…, J Truong, T Tran, RA Szeto, BS Guerra, RH Herai… - Molecular …, 2023 - nature.com
Prenatal alcohol exposure is the foremost preventable etiology of intellectual disability and
leads to a collection of diagnoses known as Fetal Alcohol Spectrum Disorders (FASD). …
leads to a collection of diagnoses known as Fetal Alcohol Spectrum Disorders (FASD). …
Genetic variations on SETD5 underlying autistic conditions
…, A Ferrasa, D Phan, RH Herai… - Developmental …, 2018 - Wiley Online Library
The prevalence of autism spectrum disorders (ASD) and the number of identified ASD‐related
genes have increased in recent years. The SETD5 gene encodes a SET‐containing‐…
genes have increased in recent years. The SETD5 gene encodes a SET‐containing‐…