User profiles for Robert Kitchen

Rob Kitchen

Head of Systems Biology & Target Discovery @ Novo Nordisk
Verified email at novonordisk.com
Cited by 4868

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

…, Y Shin, Y Zhu, AMM Sousa, DM Werling, RR Kitchen… - Science, 2018 - science.org
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Exercise hormone irisin is a critical regulator of cognitive function

…, R Luo, SF Bond, S Mazuera, RR Kitchen… - Nature …, 2021 - nature.com
Identifying secreted mediators that drive the cognitive benefits of exercise holds great promise
for the treatment of cognitive decline in ageing or Alzheimer’s disease (AD). Here, we …

The psychencode project

…, DH Kavanagh, NA Ivanov, Y Jiang, RR Kitchen… - Nature …, 2015 - nature.com
Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

[HTML][HTML] Comparative analysis of the transcriptome across distant species

…, S Jha, D Kasper, M Kato, TC Kaufman, RR Kitchen… - Nature, 2014 - nature.com
The transcriptome is the readout of the genome. Identifying common features in it across distant
species can reveal fundamental principles. To this end, the ENCODE and modENCODE …

[PDF][PDF] exRNA atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids

…, S Srinivasan, A Chung, CD Laurent, RR Kitchen… - Cell, 2019 - cell.com
To develop a map of cell-cell communication mediated by extracellular RNA (exRNA), the
NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://…

[HTML][HTML] Diverse human extracellular RNAs are widely detected in human plasma

…, E Mick, J Rozowsky, D Levy, R Kitchen… - Nature …, 2016 - nature.com
There is growing appreciation for the importance of non-protein-coding genes in development
and disease. Although much is known about microRNAs, limitations in bioinformatic …

Molecular and cellular reorganization of neural circuits in the human lineage

AMM Sousa, Y Zhu, MA Raghanti, RR Kitchen… - Science, 2017 - science.org
To better understand the molecular and cellular differences in brain organization between
human and nonhuman primates, we performed transcriptome sequencing of 16 regions of …

[PDF][PDF] Tracking distinct RNA populations using efficient and reversible covalent chemistry

…, M Rutenberg-Schoenberg, CD Stark, RR Kitchen… - Molecular cell, 2015 - cell.com
We describe a chemical method to label and purify 4-thiouridine (s 4 U)-containing RNA.
We demonstrate that methanethiosulfonate (MTS) reagents form disulfide bonds with s 4 U …

[PDF][PDF] The extracellular RNA communication consortium: establishing foundational knowledge and technologies for extracellular RNA research

…, A Khvorova, Y Kim, H Kim, TK Kim, R Kitchen… - Cell, 2019 - cell.com
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate
progress in the new field of extracellular RNA (exRNA) biology and to establish whether …

[HTML][HTML] Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

D Sproul, RR Kitchen, CE Nestor, JM Dixon, AH Sims… - Genome biology, 2012 - Springer
Background Aberrant CpG island promoter DNA hypermethylation is frequently observed in
cancer and is believed to contribute to tumor progression by silencing the expression of …