User profiles for Robert Kitchen
Rob KitchenHead of Systems Biology & Target Discovery @ Novo Nordisk Verified email at novonordisk.com Cited by 4868 |
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …
us uniquely human. The development of the brain is a highly complex process, and this …
Exercise hormone irisin is a critical regulator of cognitive function
Identifying secreted mediators that drive the cognitive benefits of exercise holds great promise
for the treatment of cognitive decline in ageing or Alzheimer’s disease (AD). Here, we …
for the treatment of cognitive decline in ageing or Alzheimer’s disease (AD). Here, we …
The psychencode project
Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …
involved in global gene regulation and chromatin modification, as well as many common …
[HTML][HTML] Comparative analysis of the transcriptome across distant species
…, S Jha, D Kasper, M Kato, TC Kaufman, RR Kitchen… - Nature, 2014 - nature.com
The transcriptome is the readout of the genome. Identifying common features in it across distant
species can reveal fundamental principles. To this end, the ENCODE and modENCODE …
species can reveal fundamental principles. To this end, the ENCODE and modENCODE …
[PDF][PDF] exRNA atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids
…, S Srinivasan, A Chung, CD Laurent, RR Kitchen… - Cell, 2019 - cell.com
To develop a map of cell-cell communication mediated by extracellular RNA (exRNA), the
NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://…
NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://…
[HTML][HTML] Diverse human extracellular RNAs are widely detected in human plasma
There is growing appreciation for the importance of non-protein-coding genes in development
and disease. Although much is known about microRNAs, limitations in bioinformatic …
and disease. Although much is known about microRNAs, limitations in bioinformatic …
Molecular and cellular reorganization of neural circuits in the human lineage
To better understand the molecular and cellular differences in brain organization between
human and nonhuman primates, we performed transcriptome sequencing of 16 regions of …
human and nonhuman primates, we performed transcriptome sequencing of 16 regions of …
[PDF][PDF] Tracking distinct RNA populations using efficient and reversible covalent chemistry
We describe a chemical method to label and purify 4-thiouridine (s 4 U)-containing RNA.
We demonstrate that methanethiosulfonate (MTS) reagents form disulfide bonds with s 4 U …
We demonstrate that methanethiosulfonate (MTS) reagents form disulfide bonds with s 4 U …
[PDF][PDF] The extracellular RNA communication consortium: establishing foundational knowledge and technologies for extracellular RNA research
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate
progress in the new field of extracellular RNA (exRNA) biology and to establish whether …
progress in the new field of extracellular RNA (exRNA) biology and to establish whether …
[HTML][HTML] Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns
Background Aberrant CpG island promoter DNA hypermethylation is frequently observed in
cancer and is believed to contribute to tumor progression by silencing the expression of …
cancer and is believed to contribute to tumor progression by silencing the expression of …