We report here that cells co-purifying with mesenchymal stem cells—termed here multipotent
adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into …

Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to
humanity. Because of its recent emergence, there is a paucity of information regarding viral …

Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly
due to delayed detection. We hypothesized that intercellular communication is critical for …

We have derived from normal human, mouse, and rat postnatal bone marrow primitive,
multipotent adult progenitor cells (MAPCs) that can differentiate into most mesodermal cells and …

Morbidity and mortality in response to SARS-CoV-2 infection are significantly elevated in
people of advanced age. To understand the underlying biology of this phenotype, we utilize the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with the …

Disclosures: MR Looney reported" other" from Neutrolis outside the submitted work. RE
Schwartz is a Sponsored Advisory Board Member for Miromatrix Inc. JD Spicer reported …

Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2
infection 1 , 2 , but the host response at the lung tissue level is poorly understood. Here we …

SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological
models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 …

Recent studies have provided insights into the pathology of and immune response to COVID-19
1 , 2 , 3 , 4 , 5 , 6 , 7 – 8 . However, a thorough investigation of the interplay between …