With the trend of moving molecular tests from clinical laboratories to on-site testing, there is
a need for nucleic acid based diagnostic tools combining the sensitivity, specificity and …

The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism
for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-…

More than half of the human genome consists of repetitive sequences, with the ribosomal
DNA (rDNA) representing two of the largest repeats. Repetitive rDNA sequences may form a …

Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in
human cell division remains elusive. We show that mammalian cells lacking survivin are …

Integrin-mediated leukocyte adhesion is a critical aspect of leukocyte function that is tightly
regulated by diverse stimuli, including chemokines, antigen receptors, and adhesion …

Polo-like kinase-1 (Plk1) performs multiple essential functions during the cell cycle. Here we
show that human Plk1-deficient cells are unable to separate their centrosomes, fail to form a …

The small GTPase Rap1 has been implicated in both negative and positive control of Ras‐mediated
signalling events. We have investigated which extracellular signals can activate …

Greatwall (Gwl) was originally discovered in Drosophila as an essential kinase for correct
chromosome condensation and mitotic progression. In Xenopus, Gwl may influence the …

Rlf is a ubiquitously expressed distinct relative of RalGDS that interacts with active Ras in
vitro. We now demonstrate that Rlf, when co-expressed with Ras mutants, associates in vivo …

Accurate chromosome segregation relies on the mitotic spindle checkpoint. This checkpoint
acts to restrict ubiquitin ligase activity of the Anaphase-promoting complex (APC/C) in …