Prion protein and Aβ‐related synaptic toxicity impairment

…, M Nuvolone, O Mirante, R Moos… - EMBO molecular …, 2010 - embopress.org
Alzheimer's disease (AD), the most common neurodegenerative disorder, goes along with
extracellular amyloid‐β (Aβ) deposits. The cognitive decline observed during AD progression …

[HTML][HTML] The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes

M Polymenidou, R Moos, M Scott, C Sigurdson, Y Shi… - PloS one, 2008 - journals.plos.org
PrP Sc , a misfolded and aggregated form of the cellular prion protein PrP C , is the only
defined constituent of the transmissible agent causing prion diseases. Expression of PrP C in …

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

…, B Ballmer, S Li, G Hutter, P Schwarz, R Moos… - Journal of Experimental …, 2010 - rupress.org
Progressive accumulation of PrP Sc , a hallmark of prion diseases, occurs when conversion
of PrP C into PrP Sc is faster than PrP Sc clearance. Engulfment of apoptotic bodies by …

[HTML][HTML] The comprehensive native interactome of a fully functional tagged prion protein

D Rutishauser, KD Mertz, R Moos, E Brunner… - PLoS …, 2009 - journals.plos.org
The enumeration of the interaction partners of the cellular prion protein, PrP C , may help
clarifying its elusive molecular function. Here we added a carboxy proximal myc epitope tag to …

Glial activation in prion diseases is selectively triggered by neuronal PrPSc

…, M Nuvolone, J Guo, P Schwarz, R Moos… - Brain …, 2022 - Wiley Online Library
Although prion infections cause cognitive impairment and neuronal death, transcriptional
and translational profiling shows progressive derangement within glia but surprisingly little …

Canine MDCK cell lines are refractory to infection with human and mouse prions

M Polymenidou, H Trusheim, L Stallmach, R Moos… - Vaccine, 2008 - Elsevier
Influenza vaccine production in embryonated eggs is associated with many disadvantages,
and production in cell culture systems is a viable alternative. Madin Darby canine kidney (…

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

C Zhu, US Herrmann, B Li, I Abakumova, R Moos… - Neurobiology of …, 2015 - Elsevier
Dysfunctional variants of the innate immune cell surface receptor TREM2 (triggering receptor
expressed on myeloid cells-2) were identified as major genetic risk factors for Alzheimer’s …

Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34–p35, and expression

R Koesters, V Adams, D Betts, R Moos, M Schmid… - Genomics, 1999 - Elsevier
We report the cloning and characterization of the human eukaryotic protein translation initiation
factor EIF2C1 gene. The human EIF2C1 gene consists of 19 exons and 18 introns that …

[HTML][HTML] Cystatin F is a biomarker of prion pathogenesis in mice

M Nuvolone, N Schmid, G Miele, S Sorce, R Moos… - PLoS …, 2017 - journals.plos.org
Misfolding of the cellular prion protein (PrP C ) into the scrapie prion protein (PrP Sc ) results
in progressive, fatal, transmissible neurodegenerative conditions termed prion diseases. …

[HTML][HTML] Neurotoxic antibodies against the prion protein do not trigger prion replication

…, S Sorce, A Senatore, P Schwarz, R Moos… - PloS one, 2016 - journals.plos.org
Prions are the infectious agents causing transmissible spongiform encephalopathies (TSE),
progressive, inexorably lethal neurological diseases. Antibodies targeting the globular …