R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease
…, H Ohigashi, Y Yokoi, R Sugimoto… - Journal of experimental …, 2017 - rupress.org
The intestinal microbial ecosystem is actively regulated by Paneth cell–derived antimicrobial
peptides such as α-defensins. Various disorders, including graft-versus-host disease (…
peptides such as α-defensins. Various disorders, including graft-versus-host disease (…
[HTML][HTML] Essential role of IFN-γ in T cell–associated intestinal inflammation
Paneth cells contribute to small intestinal homeostasis by secreting antimicrobial peptides
and constituting the intestinal stem cell (ISC) niche. Certain T cell–mediated enteropathies are …
and constituting the intestinal stem cell (ISC) niche. Certain T cell–mediated enteropathies are …
Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense
…, K Nakamura, Y Yokoi, R Sugimoto… - Proceedings of the …, 2022 - National Acad Sciences
Paneth cells are intestinal epithelial cells that release antimicrobial peptides, such as α-defensin
as part of host defense. Together with mesenchymal cells, Paneth cells provide niche …
as part of host defense. Together with mesenchymal cells, Paneth cells provide niche …
[HTML][HTML] Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids
…, K Nakamura, T Yoneda, M Kikuchi, R Sugimoto… - Scientific reports, 2019 - nature.com
Paneth cells at the base of small intestinal crypts secrete granules containing α-defensins in
response to bacteria and maintain the intestinal environment by clearing enteric pathogens …
response to bacteria and maintain the intestinal environment by clearing enteric pathogens …
[HTML][HTML] Butyric acid and leucine induce α-defensin secretion from small intestinal Paneth cells
A Takakuwa, K Nakamura, M Kikuchi, R Sugimoto… - Nutrients, 2019 - mdpi.com
The intestine not only plays a role in fundamental processes in digestion and nutrient
absorption, but it also has a role in eliminating ingested pathogenic bacteria and viruses. Paneth …
absorption, but it also has a role in eliminating ingested pathogenic bacteria and viruses. Paneth …
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice
…, S Nakamura, S Ohira, R Sugimoto… - Life Science …, 2020 - life-science-alliance.org
Crohn’s disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption
of the intestinal microbiota, is associated with CD pathophysiology. ER stress, disruption of …
of the intestinal microbiota, is associated with CD pathophysiology. ER stress, disruption of …
Perchlorate contamination of groundwater from fireworks manufacturing area in South India
Perchlorate contamination was investigated in groundwater and surface water from Sivakasi
and Madurai in the Tamil Nadu State of South India. Sensitive determination of perchlorate (…
and Madurai in the Tamil Nadu State of South India. Sensitive determination of perchlorate (…
[HTML][HTML] Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method
Y Yokoi, T Adachi, R Sugimoto, M Kikuchi… - Biochemical and …, 2021 - Elsevier
Paneth cells and Lgr5+ intestinal stem cells (Lgr5+ ISCs) constitute the stem cell niche and
maintain small intestinal epithelial integrity by recognizing various niche factors derived from …
maintain small intestinal epithelial integrity by recognizing various niche factors derived from …
Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells
…, T Yamamoto, M Shimada, R Sugimoto… - Biochemical and …, 2018 - Elsevier
Near-haploidy is observed in certain cancer types, but ploidy-dependent alterations in gene
regulation in the haploid state remain elusive. Here, by comparative transcriptome analysis …
regulation in the haploid state remain elusive. Here, by comparative transcriptome analysis …
Perioperative heart rate variability analysis to evaluate autonomic activity in gynecologic patients
…, Y Osawa, M Oishi, H Washima, R Sugimoto… - Hirosaki Medical …, 2022 - jstage.jst.go.jp
Background: Women often experience medically unexplained symptoms as they age, and
their possible causes include changes in autonomic activity. Heart rate variability is a relevant …
their possible causes include changes in autonomic activity. Heart rate variability is a relevant …