R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

…, H Ohigashi, Y Yokoi, R Sugimoto… - Journal of experimental …, 2017 - rupress.org
The intestinal microbial ecosystem is actively regulated by Paneth cell–derived antimicrobial
peptides such as α-defensins. Various disorders, including graft-versus-host disease (…

[HTML][HTML] Essential role of IFN-γ in T cell–associated intestinal inflammation

Y Eriguchi, K Nakamura, Y Yokoi, R Sugimoto… - JCI insight, 2018 - ncbi.nlm.nih.gov
Paneth cells contribute to small intestinal homeostasis by secreting antimicrobial peptides
and constituting the intestinal stem cell (ISC) niche. Certain T cell–mediated enteropathies are …

Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense

…, K Nakamura, Y Yokoi, R Sugimoto… - Proceedings of the …, 2022 - National Acad Sciences
Paneth cells are intestinal epithelial cells that release antimicrobial peptides, such as α-defensin
as part of host defense. Together with mesenchymal cells, Paneth cells provide niche …

[HTML][HTML] Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids

…, K Nakamura, T Yoneda, M Kikuchi, R Sugimoto… - Scientific reports, 2019 - nature.com
Paneth cells at the base of small intestinal crypts secrete granules containing α-defensins in
response to bacteria and maintain the intestinal environment by clearing enteric pathogens …

[HTML][HTML] Butyric acid and leucine induce α-defensin secretion from small intestinal Paneth cells

A Takakuwa, K Nakamura, M Kikuchi, R Sugimoto… - Nutrients, 2019 - mdpi.com
The intestine not only plays a role in fundamental processes in digestion and nutrient
absorption, but it also has a role in eliminating ingested pathogenic bacteria and viruses. Paneth …

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice

…, S Nakamura, S Ohira, R Sugimoto… - Life Science …, 2020 - life-science-alliance.org
Crohn’s disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption
of the intestinal microbiota, is associated with CD pathophysiology. ER stress, disruption of …

Perchlorate contamination of groundwater from fireworks manufacturing area in South India

T Isobe, SP Ogawa, R Sugimoto, K Ramu… - Environmental …, 2013 - Springer
Perchlorate contamination was investigated in groundwater and surface water from Sivakasi
and Madurai in the Tamil Nadu State of South India. Sensitive determination of perchlorate (…

[HTML][HTML] Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method

Y Yokoi, T Adachi, R Sugimoto, M Kikuchi… - Biochemical and …, 2021 - Elsevier
Paneth cells and Lgr5+ intestinal stem cells (Lgr5+ ISCs) constitute the stem cell niche and
maintain small intestinal epithelial integrity by recognizing various niche factors derived from …

Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells

…, T Yamamoto, M Shimada, R Sugimoto… - Biochemical and …, 2018 - Elsevier
Near-haploidy is observed in certain cancer types, but ploidy-dependent alterations in gene
regulation in the haploid state remain elusive. Here, by comparative transcriptome analysis …

Perioperative heart rate variability analysis to evaluate autonomic activity in gynecologic patients

…, Y Osawa, M Oishi, H Washima, R Sugimoto… - Hirosaki Medical …, 2022 - jstage.jst.go.jp
Background: Women often experience medically unexplained symptoms as they age, and
their possible causes include changes in autonomic activity. Heart rate variability is a relevant …