THE genetic loci agouti and extension control the relative amounts of eumelanin (brown–black)
and phaeomelanin (yellow–red) pigments in mammals 1 : extension encodes the …

The agouti (a) locus acts within the microenvironment of the hair follicle to regulate coat color
pigmentation in the mouse. We have characterized a gene encoding a novel 131 amino …

ABSTRACT Analysis of several mutations in the mouse is providing useful insights into the
nature of the genes required for the establishment of the left-right axis during early …

A line of transgenic mice was generated that contains an insertional mutation causing a
phenotype similar to human autosomal recessive polycystic kidney disease. Homozygotes …

We have determined the molecular basis for Usher syndrome type 1F (USH1F) in two families
segregating for this type of syndromic deafness. By fluorescence in situ hybridization, we …

The neuroepithelia of the inner ear contain hair cells that function as mechanoreceptors to
transduce sound and motion signals. Mutations affecting these neuroepithelia cause …

The agouti gene normally confers the wild-type coat color of mice. Dominant mutations at the
agouti locus result in a pleiotropic syndrome that is characterized by excessive amounts of …

RADx — Rapid Scaling Up of Covid-19 Testing In April 2020, Congress appropriated $1.5
billion to the NIH to increase national testing capacity for SARS-CoV-2. The NIH established …

A consistent phenotype observed in both human patients and several different mouse models
of autosomal recessive polycystic kidney disease (ARPKD) is an increased activity of the …

Lethal yellow (Ay) is a mutation at the mouse agouti locus in chromosome 2 that causes a
number of dominant pleiotropic effects, including a completely yellow coat color, obesity, an …