User profiles for Richard M Epand
Richard EpandProfessor of Biochemistry, McMaster University Verified email at mcmaster.ca Cited by 36534 |
[HTML][HTML] Diversity of antimicrobial peptides and their mechanisms of action
Antimicrobial peptides encompass a wide variety of structural motifs. Many peptides have α-helical
structures. The majority of these peptides are cationic and amphipathic but there are …
structures. The majority of these peptides are cationic and amphipathic but there are …
[HTML][HTML] Lipid domains in bacterial membranes and the action of antimicrobial agents
RM Epand, RF Epand - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
There has been increasing interest in recent years in describing the lateral organization of
membranes and the formation of membrane domains. Much of the focus in this area has been …
membranes and the formation of membrane domains. Much of the focus in this area has been …
[HTML][HTML] Molecular mechanisms of membrane targeting antibiotics
RM Epand, C Walker, RF Epand… - Biochimica et Biophysica …, 2016 - Elsevier
The bacterial membrane provides a target for antimicrobial peptides. There are two groups
of bacteria that have characteristically different surface membranes. One is the Gram-…
of bacteria that have characteristically different surface membranes. One is the Gram-…
Relationship of membrane curvature to the formation of pores by magainin 2
…, M Ueha, S Nakata, K Miyajima, RM Epand - Biochemistry, 1998 - ACS Publications
Magainin 2, an antimicrobial peptide from the Xenopus skin, kills bacteria by permeabilizing
the cell membranes. We have proposed that the peptide preferentially interacts with acidic …
the cell membranes. We have proposed that the peptide preferentially interacts with acidic …
[HTML][HTML] Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins)
Ceragenins are cationic bile salt derivatives having antimicrobial activity. The interactions of
several ceragenins with phospholipid bilayers were tested in different systems. The …
several ceragenins with phospholipid bilayers were tested in different systems. The …
Mimicry of antimicrobial host-defense peptides by random copolymers
…, DA Kissounko, RF Epand, RM Epand… - Journal of the …, 2007 - ACS Publications
Efforts to generate antibacterial agents via mimicry of host-defense peptides have focused
on discrete oligomers that can adopt a regular globally amphiphilic conformation in the …
on discrete oligomers that can adopt a regular globally amphiphilic conformation in the …
Lipid polymorphism and protein–lipid interactions
RM Epand - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1998 - Elsevier
Non-lamellar-forming lipids play an important role in determining the physical properties of
membranes. They affect the activity of membrane proteins and peptides. In addition, peptides …
membranes. They affect the activity of membrane proteins and peptides. In addition, peptides …
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
…, J Xia, D Pinchev, J Taylor, RM Epand… - Human molecular …, 2007 - academic.oup.com
Huntington's disease is caused by an expanded polyglutamine tract in huntingtin protein,
leading to accumulation of huntingtin in the nuclei of striatal neurons. The 18 amino-acid amino…
leading to accumulation of huntingtin in the nuclei of striatal neurons. The 18 amino-acid amino…
Bacterial membrane lipids in the action of antimicrobial agents
RM Epand, RF Epand - Journal of Peptide Science, 2011 - Wiley Online Library
Many antimicrobial agents that target bacteria are cationic and can interact with the anionic
lipid components that are exposed on the bacterial membrane. Bacteria vary widely in the …
lipid components that are exposed on the bacterial membrane. Bacteria vary widely in the …
Tocopherols and tocotrienols in membranes: a critical review
J Atkinson, RF Epand, RM Epand - Free radical biology and medicine, 2008 - Elsevier
The familiar role of tocols (tocopherols and tocotrienols) as lipid-soluble chain-terminating
inhibitors of lipid peroxidation is currently in the midst of a reinterpretation. New biological …
inhibitors of lipid peroxidation is currently in the midst of a reinterpretation. New biological …