User profiles for Richard K Assoian

Richard Assoian

University of Pennsylvania
Verified email at pennmedicine.upenn.edu
Cited by 29297

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

AB Roberts, MB Sporn, RK Assoian… - Proceedings of the …, 1986 - National Acad Sciences
Transforming growth factor type beta (TGF-beta), when injected subcutaneously in newborn
mice, causes formation of granulation tissue (induction of angiogenesis and activation of …

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

RK Assoian, A Komoriya, CA Meyers, DM Miller… - Journal of Biological …, 1983 - Elsevier
Acidic ethanol extracts of human platelets induced non-neoplastic normal rat kidney fibroblasts
to undergo anchorage-independent growth. Less than 100 ng/ml of the crude extract …

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

…, JA Jarrett, EY Chen, DH Eaton, JR Bell, RK Assoian… - Nature, 1985 - nature.com
The partial amino-acid sequence of purified human transforming growth factor-β (TGF-β)
was used to identify a series of cDNA clones encoding the protein. The cDNA sequence …

Transforming growth factor-β: biological function and chemical structure

MB Sporn, AB Roberts, LM Wakefield, RK Assoian - Science, 1986 - science.org
Transforming growth factor-β (TGF-β) is a multifunctional peptide that controls proliferation,
differentiation, and other functions in many cell types. Many cells synthesize TGF-β and …

Expression and secretion of type beta transforming growth factor by activated human macrophages.

RK Assoian, BE Fleurdelys… - Proceedings of the …, 1987 - National Acad Sciences
Alveolar macrophages activated with concanavalin A and peripheral blood monocytes activated
with lipopolysaccharide secrete type beta transforming growth factor (TGF-beta). There …

Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways

MA Schwartz, RK Assoian - Journal of cell science, 2001 - journals.biologists.com
Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated
adhesion to the extracellular matrix and by binding of growth factors to their receptors. This …

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

RK Assoian, MB Sporn - The Journal of cell biology, 1986 - rupress.org
A specific radioimmunoassay for type beta transforming growth factor (TGF-beta) was
developed and used to show that human platelets treated with thrombin release TGF-beta as a …

Integrating the MAP kinase signal into the G1 phase cell cycle machinery

K Roovers, RK Assoian - Bioessays, 2000 - Wiley Online Library
Growth factors and the extracellular matrix provide the environmental cues that control the
proliferation of most cell types. The binding of growth factors and matrix proteins to receptor …

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

…, G Cassani, F Blasi, RK Assoian - Proceedings of the …, 1985 - National Acad Sciences
The purified amino-terminal fragment (ATF) of human urokinase plasminogen activator (residues
1-135), which is not required for activation of plasminogen, binds with high affinity to …

Cellular transformation by coordinated action of three peptide growth factors from human platelets

RK Assoian, GR Grotendorst, DM Miller, MB Sporn - Nature, 1984 - nature.com
Platelet-derived growth factor 1–4 (PDGF) is known to be involved in regulating the mitosis
of connective tissue cells, and recent studies have also shown that it may function in …