We herein present an overview of the upcoming 5 th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

Epidermal lineage commitment occurs when multipotent stem cells are specified to three
lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a …

Based on the profile of genetic alterations occurring in tumor samples from selected diffuse
large B-cell lymphoma (DLBCL) patients, 2 recent whole-exome sequencing studies …

Background Biologically distinct subtypes of diffuse large B-cell lymphoma can be identified
using gene-expression analysis to determine their cell of origin, corresponding to germinal …

Purpose Biologic heterogeneity is a feature of diffuse large B-cell lymphoma (DLBCL), and
the existence of a subgroup with poor prognosis and phenotypic proximity to Burkitt …

Background Specification of primordial germ cells (PGCs) results in the conversion of pluripotent
epiblast cells into monopotent germ cell lineage. Blimp1/Prmt5 complex plays a critical …

CD19 is a coreceptor that amplifies signaling by membrane immunoglobulin (mIg) to promote
responses of the B lymphocyte to T-dependent antigens. Vav is a guanine nucleotide …

B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor
Vav-2. However, the immune responses to type II thymus-independent antigen as well as …

Plasma cells (PCs), the terminal effectors of humoral immunity, are short-lived unless supported
by niche environments in which they may persist for years. No model system has linked …

Human cytomegalovirus (CMV) induces the formation of effector CD8 + T cells that are
maintained for decades during the latent stage of infection. Effector CD8 + T cells appear …