User profiles for René Bernards
 | Rene BernardsNetherlands Cancer Institute Verified email at nki.nl Cited by 89457 |
Gene expression profiling predicts clinical outcome of breast cancer
…, RM Kerkhoven, C Roberts, PS Linsley, R Bernards… - nature, 2002 - nature.com
Breast cancer patients with the same stage of disease can have markedly different treatment
responses and overall outcome. The strongest predictors for metastases (for example, …
responses and overall outcome. The strongest predictors for metastases (for example, …
Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR
Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug PLX4032 (vemurafenib)
is highly effective in the treatment of melanoma 1 . However, colon cancer patients …
is highly effective in the treatment of melanoma 1 . However, colon cancer patients …
[HTML][HTML] A genomic and functional inventory of deubiquitinating enzymes
Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies. …
event, and the enzymes catalyzing these modifications have been the focus of many studies. …
[PDF][PDF] A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
…, GB Mills, MJ Van De Vijver, R Bernards - Cancer cell, 2007 - cell.com
A large-scale RNA interference screen to discover genes involved in trastuzumab resistance
in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants …
in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants …
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
…, M van der Ven, M Wetering, DA Egan, R Bernards… - elife, 2016 - elifesciences.org
10.7554/eLife.18489.001 Colorectal cancer (CRC) organoids can be derived from almost all
CRC patients and therefore capture the genetic diversity of this disease. We assembled a …
CRC patients and therefore capture the genetic diversity of this disease. We assembled a …
A system for stable expression of short interfering RNAs in mammalian cells
Mammalian genetic approaches to study gene function have been hampered by the lack of
tools to generate stable loss-of-function phenotypes efficiently. We report here a new vector …
tools to generate stable loss-of-function phenotypes efficiently. We report here a new vector …
[HTML][HTML] A gene-expression signature as a predictor of survival in breast cancer
Background A more accurate means of prognostication in breast cancer will improve the
selection of patients for adjuvant systemic therapy. Methods Using microarray analysis to …
selection of patients for adjuvant systemic therapy. Methods Using microarray analysis to …
[HTML][HTML] 70-gene signature as an aid to treatment decisions in early-stage breast cancer
…, P Vuylsteke, R Bernards… - … England Journal of …, 2016 - Mass Medical Soc
Background The 70-gene signature test (MammaPrint) has been shown to improve
prediction of clinical outcome in women with early-stage breast cancer. We sought to provide …
prediction of clinical outcome in women with early-stage breast cancer. We sought to provide …
[PDF][PDF] Stable suppression of tumorigenicity by virus-mediated RNA interference
Most human tumors harbor multiple genetic alterations, including dominant mutant oncogenes.
It is often not clear which of these oncogenes are continuously required and which, when …
It is often not clear which of these oncogenes are continuously required and which, when …
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic
screens in lower organisms and can greatly facilitate the identification of components of …
screens in lower organisms and can greatly facilitate the identification of components of …