Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …

Invasion, metastasis and therapy resistance are the major cause of cancer‐associated deaths,
and the EMT ‐inducing transcription factor ZEB 1 is a crucial stimulator of these processes…

Protein kinase A is a key mediator of cAMP signalling downstream of G-protein-coupled
receptors, a signalling pathway conserved in all eukaryotes. cAMP binding to the regulatory …

Osteosarcoma is an often‐fatal mesenchyme‐derived malignancy in children and young
adults. Overexpression of EMT‐transcription factors (EMT‐TFs) has been associated with poor …

Ubiquitin‐specific protease 33 (USP33) is a deubiquitinase that has been associated with a
variety of physiological events. Here, we show the existence of multiple USP33 splice …

Systematic analysis of human arginine methylation identifies two distinct signaling modes;
either isolated modifications akin to canonical post-translational modification regulation, or …

Rho GTPases control cell shape formation and thus fundamental physiological processes in
all eukaryotes. Their functions are regulated by 145 RhoGEF and RhoGAP multi-domain …

Systematic analysis of human arginine methylation identifies two distinct signaling modes;
either isolated modifications akin to canonical post-translational modification regulation, or …

Systematic analysis of human arginine methylation events bifurcates its signaling mechanism,
functioning either in isolation akin to canonical PTM regulation or clustered within …