During physical exercise, increases in motor neuron activity stimulate the expression of
muscle-specific genes through the myocyte enhancer factor 2 (MEF2) family of transcription …

Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas, heart …

Infections disturb metabolic homeostasis in many contexts, but the underlying connections
are not completely understood. To address this, we use paired genetic and computational …

Among organ systems, skeletal muscle is perhaps the most structurally specialized. The
remarkable subcellular architecture of this tissue allows it to empower movement with …

The adipose-derived hormone leptin maintains energy balance in part through central nervous
system-mediated increases in sympathetic outflow that enhance fat burning. Triggering of …

Transformation of fibroblasts by oncogenic Src causes disruption of actin stress fibers and
formation of invasive adhesions called podosomes. Because the small GTPase Rho …

Immune checkpoint blockade (ICB) targeting PD-1 and CTLA-4 has revolutionized cancer
treatment. However, many cancers do not respond to ICB, prompting the search for additional …

The tumor suppressor LKB1/STK11 encodes a serine/threonine kinase frequently inactivated
in NSCLC. LKB1 activates 14 downstream kinases in the AMPK family controlling growth …

SnoN is an important negative regulator of transforming growth factor β signaling through its
ability to interact with and repress the activity of Smad proteins. It was originally identified as …

Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene expression
with potent tumor suppressor activity, yet many liver tumors express HNF4α. This study …