The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine
mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion …

Mutations in FBXL4 (F-Box and Leucine rich repeat protein 4), a nuclear-encoded mitochondrial
protein with an unknown function, cause mitochondrial DNA depletion syndrome. We …

Exome sequencing of two sisters with congenital cataracts, short stature, and white matter
changes identified compound heterozygous variants in the PISD gene, encoding the …

The dynamic nature of mitochondria, which can fuse, divide and move throughout the cell,
allows these critical organelles to adapt their function in response to cellular demands, and is …

Mitochondrial DNA (mtDNA) maintenance is essential to sustain a functionally healthy
population of mitochondria within cells. Proper mtDNA replication and distribution within …

Aims: Mitochondrial function is coupled to metabolic and survival pathways through both
direct signaling cascades and dynamic changes in mitochondrial morphology. For example, a …

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder that
exhibits a common set of behavioral and cognitive impairments. Although the etiology of ASD …

Background & Aims Mitochondria exist in a constantly remodelling network, and excessive
fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric …

Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering
and regenerative medicine. MSCs can promote host tissue repair through several different …

Background Dilated cardiomyopathy with ataxia syndrome (DCMA) is an understudied
autosomal recessive disease caused by loss-of-function mutations in the poorly characterized …